Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction

Edda Bilek, Axel Schäfer, Elisabeth Ochs, Christine Esslinger, Maria Zangl, Michael M. Plichta, Urs Braun, Peter Kirsch, Thomas G. Schulze, Marcella Rietschel, Andreas Meyer-Lindenberg, Heike Tost

Research output: Contribution to journalArticle

Abstract

Neural plasticity is crucial for understanding the experience-dependent reorganization of brain regulatory circuits and the pathophysiology of schizophrenia. An important circuit-level feature derived from functional magnetic resonance imaging (fMRI) is prefrontal-hippocampal seeded connectivity during working memory, the best established intermediate connectivity phenotype of schizophrenia risk to date. The phenotype is a promising marker for the effects of plasticity-enhancing interventions, such as high-frequency repetitive transcranial magnetic stimulation (rTMS), and can be studied in healthy volunteers in the absence of illness-related confounds, but the relationship to brain plasticity is unexplored. We recruited 39 healthy volunteers to investigate the effects of 5 Hz rTMS on prefrontal-hippocampal coupling during working memory and rest. In a randomized and sham-controlled experiment, neuronavigation-guided rTMS was applied to the right dorsolateral prefrontal cortex (DLPFC), and fMRI and functional connectivity analyses [seeded connectivity and psychophysiological interaction (PPI)] were used as readouts. Moreover, the test-retest reliability of working-memory related connectivity markers was evaluated. rTMS provoked a significant decrease in seeded functional connectivity of the right DLPFC and left hippocampus during working memory that proved to be relatively time-invariant and robust. PPI analyses provided evidence for a nominal effect of rTMS and poor test-retest reliability. No effects on n-back-related activation and DLPFC-hippocampus resting-state connectivity were observed. These data provide the first in vivo evidence for the effects of plasticity induction on human prefrontal-hippocampal network dynamics, offer insights into the biological mechanisms of a well established intermediate phenotype linked to schizophrenia, and underscores the importance of the choice of outcome measures in test-retest designs.

Original languageEnglish (US)
Pages (from-to)7050-7056
Number of pages7
JournalJournal of Neuroscience
Volume33
Issue number16
DOIs
StatePublished - Apr 17 2013
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    Bilek, E., Schäfer, A., Ochs, E., Esslinger, C., Zangl, M., Plichta, M. M., Braun, U., Kirsch, P., Schulze, T. G., Rietschel, M., Meyer-Lindenberg, A., & Tost, H. (2013). Application of high-frequency repetitive transcranial magnetic stimulation to the DLPFC alters human prefrontal-hippocampal functional interaction. Journal of Neuroscience, 33(16), 7050-7056. https://doi.org/10.1523/JNEUROSCI.3081-12.2013