Application of Graph Theory to Assess Static and Dynamic Brain Connectivity: Approaches for Building Brain Graphs

Qingbao Yu, Yuhui Du, Jiayu Chen, Jing Sui, Tulay Adali, Godfrey D. Pearlson, Vince D. Calhoun

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Human brain connectivity is complex. Graph-theorybased analysis has become a powerful and popular approach for analyzing brain imaging data, largely because of its potential to quantitatively illuminate the networks, the static architecture in structure and function, the organization of dynamic behavior over time, and disease related brain changes. The first step in creating brain graphs is to define the nodes and edges connecting them. We review a number of approaches for defining brain nodes including fixed versus data-driven nodes. Expanding the narrow view of most studies which focus on static and/or single modality brain connectivity, we also survey advanced approaches and their performances in building dynamic and multimodal brain graphs. We show results from both simulated and real data from healthy controls and patients with mental illnesses. We outline the advantages and challenges of these various techniques. By summarizing and inspecting recent studies which analyzed brain imaging data based on graph theory, this paper provides a guide for developing new powerful tools to explore complex brain networks.

Original languageEnglish (US)
Pages (from-to)886-906
Number of pages21
JournalProceedings of the IEEE
Volume106
Issue number5
DOIs
StatePublished - May 2018

Keywords

  • Brain graph
  • dynamic
  • multimodal
  • nodes

ASJC Scopus subject areas

  • General Computer Science
  • Electrical and Electronic Engineering

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