Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images: Typically Developing and Spinal Cord Injury Population

Mahdi Alizadeh, Pallav Shah, Chris J. Conklin, Devon M. Middleton, Sona Saksena, Adam E. Flanders, Laura Krisa, M. J. Mulcahey, Scott Faro, Feroze B. Mohamed

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate an improved and reliable visualization method for pediatric spinal cord MR images in healthy subjects and patients with spinal cord injury (SCI). A total of 15 pediatric volunteers (10 healthy subjects and 5 subjects with cervical SCI) with a mean age of 11.41 years (range 8–16 years) were recruited and scanned using a 3.0T Siemens Verio MR scanner. T2-weighted axial images were acquired covering entire cervical spinal cord level C1 to C7. These gray-scale images were then converted to color images by using five different techniques including hue-saturation-value (HSV), rainbow, red-green-blue (RGB), and two enhanced RGB techniques using automated contrast stretching and intensity inhomogeneity correction. Performance of these techniques was scored visually by two neuroradiologists within three selected cervical spinal cord intervertebral disk levels (C2-C3, C4-C5, and C6-C7) and quantified using signal to noise ratio (SNR) and contrast to noise ratio (CNR). Qualitative and quantitative evaluation of the color images shows consistent improvement across all the healthy and SCI subjects over conventional gray-scale T2-weighted gradient echo (GRE) images. Inter-observer reliability test showed moderate to strong intra-class correlation (ICC) coefficients in the proposed techniques (ICC > 0.73). The results suggest that the color images could be used for quantification and enhanced visualization of the spinal cord structures in addition to the conventional gray-scale images. This would immensely help towards improved delineation of the gray/white and CSF structures and further aid towards accurate manual or automatic drawings of region of interests (ROIs).

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Digital Imaging
DOIs
StateAccepted/In press - Jan 16 2018

Fingerprint

Pediatrics
Spinal Cord Injuries
Spinal Cord
Color
Healthy Volunteers
Population
Intervertebral Disc
Signal-To-Noise Ratio
Noise
Volunteers
Drawing (graphics)
Visualization
Cervical Cord
Stretching
Signal to noise ratio

Keywords

  • Gradient echo
  • Image enhancement
  • Pseudo-color transformation
  • Spinal cord injury

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Science Applications

Cite this

Alizadeh, M., Shah, P., Conklin, C. J., Middleton, D. M., Saksena, S., Flanders, A. E., ... Mohamed, F. B. (Accepted/In press). Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images: Typically Developing and Spinal Cord Injury Population. Journal of Digital Imaging, 1-10. https://doi.org/10.1007/s10278-017-0048-5

Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images : Typically Developing and Spinal Cord Injury Population. / Alizadeh, Mahdi; Shah, Pallav; Conklin, Chris J.; Middleton, Devon M.; Saksena, Sona; Flanders, Adam E.; Krisa, Laura; Mulcahey, M. J.; Faro, Scott; Mohamed, Feroze B.

In: Journal of Digital Imaging, 16.01.2018, p. 1-10.

Research output: Contribution to journalArticle

Alizadeh, Mahdi ; Shah, Pallav ; Conklin, Chris J. ; Middleton, Devon M. ; Saksena, Sona ; Flanders, Adam E. ; Krisa, Laura ; Mulcahey, M. J. ; Faro, Scott ; Mohamed, Feroze B. / Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images : Typically Developing and Spinal Cord Injury Population. In: Journal of Digital Imaging. 2018 ; pp. 1-10.
@article{67b6102cba764c7d9e34f2377574e23f,
title = "Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images: Typically Developing and Spinal Cord Injury Population",
abstract = "The purpose of this study was to evaluate an improved and reliable visualization method for pediatric spinal cord MR images in healthy subjects and patients with spinal cord injury (SCI). A total of 15 pediatric volunteers (10 healthy subjects and 5 subjects with cervical SCI) with a mean age of 11.41 years (range 8–16 years) were recruited and scanned using a 3.0T Siemens Verio MR scanner. T2-weighted axial images were acquired covering entire cervical spinal cord level C1 to C7. These gray-scale images were then converted to color images by using five different techniques including hue-saturation-value (HSV), rainbow, red-green-blue (RGB), and two enhanced RGB techniques using automated contrast stretching and intensity inhomogeneity correction. Performance of these techniques was scored visually by two neuroradiologists within three selected cervical spinal cord intervertebral disk levels (C2-C3, C4-C5, and C6-C7) and quantified using signal to noise ratio (SNR) and contrast to noise ratio (CNR). Qualitative and quantitative evaluation of the color images shows consistent improvement across all the healthy and SCI subjects over conventional gray-scale T2-weighted gradient echo (GRE) images. Inter-observer reliability test showed moderate to strong intra-class correlation (ICC) coefficients in the proposed techniques (ICC > 0.73). The results suggest that the color images could be used for quantification and enhanced visualization of the spinal cord structures in addition to the conventional gray-scale images. This would immensely help towards improved delineation of the gray/white and CSF structures and further aid towards accurate manual or automatic drawings of region of interests (ROIs).",
keywords = "Gradient echo, Image enhancement, Pseudo-color transformation, Spinal cord injury",
author = "Mahdi Alizadeh and Pallav Shah and Conklin, {Chris J.} and Middleton, {Devon M.} and Sona Saksena and Flanders, {Adam E.} and Laura Krisa and Mulcahey, {M. J.} and Scott Faro and Mohamed, {Feroze B.}",
year = "2018",
month = "1",
day = "16",
doi = "10.1007/s10278-017-0048-5",
language = "English (US)",
pages = "1--10",
journal = "Journal of Digital Imaging",
issn = "0897-1889",
publisher = "Springer New York",

}

TY - JOUR

T1 - Application of Color Transformation Techniques in Pediatric Spinal Cord MR Images

T2 - Typically Developing and Spinal Cord Injury Population

AU - Alizadeh, Mahdi

AU - Shah, Pallav

AU - Conklin, Chris J.

AU - Middleton, Devon M.

AU - Saksena, Sona

AU - Flanders, Adam E.

AU - Krisa, Laura

AU - Mulcahey, M. J.

AU - Faro, Scott

AU - Mohamed, Feroze B.

PY - 2018/1/16

Y1 - 2018/1/16

N2 - The purpose of this study was to evaluate an improved and reliable visualization method for pediatric spinal cord MR images in healthy subjects and patients with spinal cord injury (SCI). A total of 15 pediatric volunteers (10 healthy subjects and 5 subjects with cervical SCI) with a mean age of 11.41 years (range 8–16 years) were recruited and scanned using a 3.0T Siemens Verio MR scanner. T2-weighted axial images were acquired covering entire cervical spinal cord level C1 to C7. These gray-scale images were then converted to color images by using five different techniques including hue-saturation-value (HSV), rainbow, red-green-blue (RGB), and two enhanced RGB techniques using automated contrast stretching and intensity inhomogeneity correction. Performance of these techniques was scored visually by two neuroradiologists within three selected cervical spinal cord intervertebral disk levels (C2-C3, C4-C5, and C6-C7) and quantified using signal to noise ratio (SNR) and contrast to noise ratio (CNR). Qualitative and quantitative evaluation of the color images shows consistent improvement across all the healthy and SCI subjects over conventional gray-scale T2-weighted gradient echo (GRE) images. Inter-observer reliability test showed moderate to strong intra-class correlation (ICC) coefficients in the proposed techniques (ICC > 0.73). The results suggest that the color images could be used for quantification and enhanced visualization of the spinal cord structures in addition to the conventional gray-scale images. This would immensely help towards improved delineation of the gray/white and CSF structures and further aid towards accurate manual or automatic drawings of region of interests (ROIs).

AB - The purpose of this study was to evaluate an improved and reliable visualization method for pediatric spinal cord MR images in healthy subjects and patients with spinal cord injury (SCI). A total of 15 pediatric volunteers (10 healthy subjects and 5 subjects with cervical SCI) with a mean age of 11.41 years (range 8–16 years) were recruited and scanned using a 3.0T Siemens Verio MR scanner. T2-weighted axial images were acquired covering entire cervical spinal cord level C1 to C7. These gray-scale images were then converted to color images by using five different techniques including hue-saturation-value (HSV), rainbow, red-green-blue (RGB), and two enhanced RGB techniques using automated contrast stretching and intensity inhomogeneity correction. Performance of these techniques was scored visually by two neuroradiologists within three selected cervical spinal cord intervertebral disk levels (C2-C3, C4-C5, and C6-C7) and quantified using signal to noise ratio (SNR) and contrast to noise ratio (CNR). Qualitative and quantitative evaluation of the color images shows consistent improvement across all the healthy and SCI subjects over conventional gray-scale T2-weighted gradient echo (GRE) images. Inter-observer reliability test showed moderate to strong intra-class correlation (ICC) coefficients in the proposed techniques (ICC > 0.73). The results suggest that the color images could be used for quantification and enhanced visualization of the spinal cord structures in addition to the conventional gray-scale images. This would immensely help towards improved delineation of the gray/white and CSF structures and further aid towards accurate manual or automatic drawings of region of interests (ROIs).

KW - Gradient echo

KW - Image enhancement

KW - Pseudo-color transformation

KW - Spinal cord injury

UR - http://www.scopus.com/inward/record.url?scp=85042752984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042752984&partnerID=8YFLogxK

U2 - 10.1007/s10278-017-0048-5

DO - 10.1007/s10278-017-0048-5

M3 - Article

C2 - 29340936

AN - SCOPUS:85042752984

SP - 1

EP - 10

JO - Journal of Digital Imaging

JF - Journal of Digital Imaging

SN - 0897-1889

ER -