Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

B. Chung; P. C. Johnson; A. S. Popel

doi:10.1002/fld.1251

Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

B. Chung, P. C. Johnson, A. S. Popel

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

Original language	English (US)
Pages (from-to)	105-128
Number of pages	24
Journal	International Journal for Numerical Methods in Fluids
Volume	53
Issue number	1
DOIs	https://doi.org/10.1002/fld.1251
State	Published - Jan 10 2007

Keywords

Chimera grid
Depletion interaction energy
RBC aggregation
Red blood cell

ASJC Scopus subject areas

Computational Mechanics
Mechanics of Materials
Mechanical Engineering
Computer Science Applications
Applied Mathematics

Access to Document

10.1002/fld.1251

Cite this

@article{ebb922ba41a14492bc7f466675b4c500,

title = "Application of Chimera grid to modelling cell motion and aggregation in a narrow tube",

abstract = "A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.",

keywords = "Chimera grid, Depletion interaction energy, RBC aggregation, Red blood cell",

author = "B. Chung and Johnson, {P. C.} and Popel, {A. S.}",

year = "2007",

month = jan,

day = "10",

doi = "10.1002/fld.1251",

language = "English (US)",

volume = "53",

pages = "105--128",

journal = "International Journal for Numerical Methods in Fluids",

issn = "0271-2091",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

AU - Chung, B.

AU - Johnson, P. C.

AU - Popel, A. S.

PY - 2007/1/10

Y1 - 2007/1/10

N2 - A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

AB - A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

KW - Chimera grid

KW - Depletion interaction energy

KW - RBC aggregation

KW - Red blood cell

UR - http://www.scopus.com/inward/record.url?scp=33845645548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845645548&partnerID=8YFLogxK

U2 - 10.1002/fld.1251

DO - 10.1002/fld.1251

M3 - Article

AN - SCOPUS:33845645548

SN - 0271-2091

VL - 53

SP - 105

EP - 128

JO - International Journal for Numerical Methods in Fluids

JF - International Journal for Numerical Methods in Fluids

IS - 1

ER -

Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this