Application of Chimera grid to modelling cell motion and aggregation in a narrow tube

B. Chung, P. C. Johnson, A. S. Popel

Research output: Contribution to journalArticle


A computational scheme using the Chimera grid method is presented for simulation of three-dimensional motion and aggregation of two red blood cells (RBCs) in a narrow tube. The cells are modelled as rigid ellipsoidal particles; the computational scheme is applicable to deformable fluid-filled particles. Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. Through the simulation, we show that the Chimera grid method is applicable to the simulation of three-dimensional motion and aggregation of multiple RBCs in a microvessel and microvascular network.

Original languageEnglish (US)
Pages (from-to)105-128
Number of pages24
JournalInternational Journal for Numerical Methods in Fluids
Issue number1
StatePublished - Jan 10 2007



  • Chimera grid
  • Depletion interaction energy
  • RBC aggregation
  • Red blood cell

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanics of Materials
  • Mechanical Engineering
  • Computer Science Applications
  • Applied Mathematics

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