Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting

Sarah Blythe Ballard, Aaron Tallant, Rosio G. Guerra, Dawn Quigley, Regan Stiegmann, Andrew J. Mirelman, Mark S. Riddle, Robert H. Gilman

Research output: Contribution to journalArticle

Abstract

Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific vaccine implementation resulted in calculated cost-effectiveness ratio (CER) per duty day lost averted (CERDDL) of $13,741; $1,272; $301; and $803, and a CER per diarrhea day averted of $2,130; $215; $51; and $199 for Campylobacter, ETEC, Shigella, and norovirus, respectively. These estimates compare favorably to CERDDL estimates from high-income military population and suggest that implementing vaccines gastroenteritis may be cost-effective in the Peruvian military population.

Original languageEnglish (US)
Pages (from-to)2292-2297
Number of pages6
JournalVaccine
Volume38
Issue number10
DOIs
StatePublished - Feb 28 2020

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Keywords

  • Cost-effectiveness analysis
  • Gastroenteritis
  • Low- and middle-income countries
  • Military
  • Peru
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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