Apparent diffusion coefficient scalars correlate with near-Infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-Ischemic injury

Aylin Tekes, A. Poretti, M. M. Scheurkogel, T. A G M Huisman, J. A. Howlett, E. Alqahtani, J. H. Lee, C. Parkinson, K. Shapiro, S. E. Chung, Jacky Jennings, Maureen Gilmore, C. W. Hogue, Lee J Martin, Raymond C Koehler, Frances Northington, Jennifer Lee-Summers

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. Materials and Methods: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4 -15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation. Results: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (r= -0.87, P = .003, n = 9) and the posterior limb of the internal capsule (r= -0.68, P=.04, n=9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (r= -0.71, P = .05, n = 8). Conclusions: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

Original languageEnglish (US)
Pages (from-to)188-193
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

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Near-Infrared Spectroscopy
Homeostasis
Internal Capsule
Blood Pressure
Wounds and Injuries
Basal Ganglia
Induced Hypothermia
Extremities
Rewarming
Pons
Hypothermia
Thalamus
Brain Injuries
Nervous System
Biomarkers
Morbidity
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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Apparent diffusion coefficient scalars correlate with near-Infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-Ischemic injury. / Tekes, Aylin; Poretti, A.; Scheurkogel, M. M.; Huisman, T. A G M; Howlett, J. A.; Alqahtani, E.; Lee, J. H.; Parkinson, C.; Shapiro, K.; Chung, S. E.; Jennings, Jacky; Gilmore, Maureen; Hogue, C. W.; Martin, Lee J; Koehler, Raymond C; Northington, Frances; Lee-Summers, Jennifer.

In: American Journal of Neuroradiology, Vol. 36, No. 1, 01.01.2015, p. 188-193.

Research output: Contribution to journalArticle

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abstract = "Background and Purpose: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. Materials and Methods: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4 -15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation. Results: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (r= -0.87, P = .003, n = 9) and the posterior limb of the internal capsule (r= -0.68, P=.04, n=9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (r= -0.71, P = .05, n = 8). Conclusions: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.",
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T1 - Apparent diffusion coefficient scalars correlate with near-Infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-Ischemic injury

AU - Tekes, Aylin

AU - Poretti, A.

AU - Scheurkogel, M. M.

AU - Huisman, T. A G M

AU - Howlett, J. A.

AU - Alqahtani, E.

AU - Lee, J. H.

AU - Parkinson, C.

AU - Shapiro, K.

AU - Chung, S. E.

AU - Jennings, Jacky

AU - Gilmore, Maureen

AU - Hogue, C. W.

AU - Martin, Lee J

AU - Koehler, Raymond C

AU - Northington, Frances

AU - Lee-Summers, Jennifer

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background and Purpose: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. Materials and Methods: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4 -15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation. Results: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (r= -0.87, P = .003, n = 9) and the posterior limb of the internal capsule (r= -0.68, P=.04, n=9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (r= -0.71, P = .05, n = 8). Conclusions: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

AB - Background and Purpose: Neurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. Materials and Methods: Thirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4 -15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation. Results: In neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (r= -0.87, P = .003, n = 9) and the posterior limb of the internal capsule (r= -0.68, P=.04, n=9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (r= -0.71, P = .05, n = 8). Conclusions: Blood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

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