Apoptotic Cells as a Source of Autoantigens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The autoantibody response in patients and animals with autoimmune disease exhibits clonal expansion, affinity maturation, and class switching, and provides evidence that the immune responses in these processes are antigen driven and T-cell dependent. Experimental evidence indicates that most autoantigens are indeed unified by their susceptibility to structural modification during cell death. Although autoantigens have been demonstrated to undergo several types of modification during cell death, this chapter focuses only on the proteolytic cleavage of autoantigens, and the mechanisms whereby such changes might lead to initiation of an autoimmune response. Proteases play a critical role in the apoptotic process through targeted cleavage of a limited group of downstream substrates that are functionally important in the maintenance of life. The caspases, a family of cysteine proteases with an absolute requirement for cleavage after aspartic acid, constitute the most prominent apoptotic protease family. Furthermore, it is possible that cleavage of autoantigens influences immunogenicity, it is equally likely that the presence and structural features of the cleavage site itself influence antigen processing and epitope selection, and that different mechanisms apply to different autoantigens.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
PublisherElsevier Inc.
Pages193-201
Number of pages9
ISBN (Print)9780125959612
DOIs
StatePublished - 2006

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Autoantigens
Peptide Hydrolases
Cell Death
Immunoglobulin Class Switching
Cysteine Proteases
Antigen Presentation
Caspases
Autoimmunity
Aspartic Acid
Autoantibodies
Autoimmune Diseases
Epitopes
Maintenance
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Apoptotic Cells as a Source of Autoantigens. / Casciola Rosen, Livia A; Rosen, Antony.

The Autoimmune Diseases. Elsevier Inc., 2006. p. 193-201.

Research output: Chapter in Book/Report/Conference proceedingChapter

Casciola Rosen, Livia A ; Rosen, Antony. / Apoptotic Cells as a Source of Autoantigens. The Autoimmune Diseases. Elsevier Inc., 2006. pp. 193-201
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