APOPTOTIC AN IN AN IN VITRO MODEL OF NEURONAL OXIDATIVE STRESS

Rajiv R. Ratan, Jay M. Baraban

Research output: Contribution to journalArticle

Abstract

1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this accurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine deprivation and glutathione depletion results in cell death with the morphological and biochemical features of apoptosis. 4. Neuronal apoptosis induced by oxidative stress can be inhibited by macromolecular synthesis inhibitors. 5. This in vitro model will be a valuable tool for defining the molecular targets of toxic free radicals in neurones and, in turn, in designing rational new therapies for free radical mediated diseases.

Original languageEnglish (US)
Pages (from-to)309-310
Number of pages2
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue number4
DOIs
StatePublished - Apr 1995

Keywords

  • apoptosis
  • glutathione
  • neurones
  • oxidative stress.

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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