Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei

Mi Wang, Suparna Qanungo, Michael T. Crow, Michiko Watanabe, Anna Liisa Nieminen

Research output: Contribution to journalArticlepeer-review

Abstract

Apoptosis repressor with caspase recruitment domain is expressed at high levels in brain and myogenic tissues, consistent with a role to inhibit apoptosis in the terminally differentiated cells. Expression of ARC in cancers is not known. In this study, we reported that ARC was highly expressed in various non-myogenic and non-neurogenic human and rat cancer cell lines. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells. Furthermore, nuclear ARC in cancer cells did not co-localize with nucleolus protein of 30 kDa, an alternatively spliced ARC isoform. These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)2411-2415
Number of pages5
JournalFEBS Letters
Volume579
Issue number11
DOIs
StatePublished - Apr 25 2005

Keywords

  • Apoptosis
  • Apoptosis repressor with caspase recruitment domain
  • Cancer cells

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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