Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

Hong Duk Youn, Luo Sun, Ron Prywes, Jun O. Liu

Research output: Contribution to journalArticlepeer-review

Abstract

T cell receptor (TCR)-induced apoptosis of thymocytes is mediated by calcium-dependent expression of the steroid receptors Nur77 and Nor1. Nur77 expression is controlled by the transcription factor myocyte enhancer factor 2 (MEF2), but how MEF2 is activated by calcium signaling is still obscure. Cabin 1, a calcineurin inhibitor, was found to regulate MEF2. MEF2 was normally sequestered by Cabin1 in a transcriptionally inactive state. TCR engagement led to an increase in intracellular calcium concentration and the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1. The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis.

Original languageEnglish (US)
Pages (from-to)790-793
Number of pages4
JournalScience
Volume286
Issue number5440
DOIs
StatePublished - Oct 22 1999
Externally publishedYes

ASJC Scopus subject areas

  • General

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