TY - JOUR
T1 - Apoptosis in systemic lupus erythematosus
T2 - Clinical implications
AU - Andrade, Felipe
AU - Casciola-Rosen, Livia
AU - Rosen, Antony
N1 - Funding Information:
These studies were supported by NIH Grants AR44684 (LC-R) and DE12354 (AR), the SLE Foundation, the Donald B. and Dorothy L. Stabler Foundation, and the Schauman Lupus Research Fund. Antony Rosen is a Pew Scholar in the Biomedical Sciences and is supported by a Burroughs Wellcome Fund Translational Research award. Felipe Andrade is supported by a Fullbright/Consejo Nacional de Ciencia y Tecnologia, Mexico scholarship.
PY - 2000
Y1 - 2000
N2 - SLE is a heterogeneous and complex group of disorders of uncertain cause. Recent studies have suggested that abnormalities in the apoptotic cell death process may play an important role in the initiation and propagation of this spectrum of disease by altering the generation and cleavage of antigens, and through abnormalities in immunoregulation. The clustering and concentration of autoantigens in and on the surface blebs of apoptotic cells, modifications of antigen structure during certain forms of apoptotic death, and abnormalities in apoptotic cell clearance in humans with SLE and in certain animal models are reviewed and synthesized into a comprehensive model of systemic autoimmunity.
AB - SLE is a heterogeneous and complex group of disorders of uncertain cause. Recent studies have suggested that abnormalities in the apoptotic cell death process may play an important role in the initiation and propagation of this spectrum of disease by altering the generation and cleavage of antigens, and through abnormalities in immunoregulation. The clustering and concentration of autoantigens in and on the surface blebs of apoptotic cells, modifications of antigen structure during certain forms of apoptotic death, and abnormalities in apoptotic cell clearance in humans with SLE and in certain animal models are reviewed and synthesized into a comprehensive model of systemic autoimmunity.
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U2 - 10.1016/S0889-857X(05)70136-8
DO - 10.1016/S0889-857X(05)70136-8
M3 - Article
C2 - 10768210
AN - SCOPUS:0034036862
SN - 0889-857X
VL - 26
SP - 215
EP - 227
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 2
ER -