TY - JOUR
T1 - Apoptosis and autoimmunity
AU - Mahoney, James A.
AU - Rosen, Antony
N1 - Funding Information:
Work in the authors’ laboratory is supported by grants from the National Institutes of Health (numbers DE-123544, AR-44684, and HL-56091) and the Arthritis Foundation. AR is supported by a Burroughs Wellcome Fund Translational Research Award.
PY - 2005/12
Y1 - 2005/12
N2 - Autoimmune diseases reflect the confluence of genetic, environmental and stochastic events. Recent studies have implicated apoptotic cell death pathways in initiating and propagating autoimmune diseases, as well as in rendering individuals susceptible to such diseases. Similar to autoimmunity, apoptosis is a multistep process, affecting immune and target cells, integrating numerous intrinsic and extrinsic signals, and requiring the actions of multiple gene products. Particularly relevant to the complexity of autoimmunity are the recent observations that apoptotic death might provide a primary source of tolerogen to shape the immune repertoire, or be the target of the immune response in autoimmunity, and that apoptosis is both required for lymphocyte selection and immunoregulation, and is a prominent outcome of immune and inflammatory effector pathways.
AB - Autoimmune diseases reflect the confluence of genetic, environmental and stochastic events. Recent studies have implicated apoptotic cell death pathways in initiating and propagating autoimmune diseases, as well as in rendering individuals susceptible to such diseases. Similar to autoimmunity, apoptosis is a multistep process, affecting immune and target cells, integrating numerous intrinsic and extrinsic signals, and requiring the actions of multiple gene products. Particularly relevant to the complexity of autoimmunity are the recent observations that apoptotic death might provide a primary source of tolerogen to shape the immune repertoire, or be the target of the immune response in autoimmunity, and that apoptosis is both required for lymphocyte selection and immunoregulation, and is a prominent outcome of immune and inflammatory effector pathways.
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U2 - 10.1016/j.coi.2005.09.018
DO - 10.1016/j.coi.2005.09.018
M3 - Review article
C2 - 16214321
AN - SCOPUS:27144518186
SN - 0952-7915
VL - 17
SP - 583
EP - 588
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -