Apolipoproteins are a mediator of tissue-specificity in the foreign body response

Kaitlyn Sadtler, Corina Macisaac, Francisco Zepeda, Joshua Doloff, Robert S. Langer, Daniel G. Anderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The theory of tissue-based class control, developed by Matzinger 1 , suggests that the immune response to a pathogen is not primarily tailored to the pathogen identity but instead the tissue location of that infection. We propose that this theory also plays a role in biomaterials and medical device implantation wherein the tissue microenvironment greatly regulates the response to the implanted material or device. White adipose is associated with pro-fibrotic and inflammatory responses in the context of implanted devices 2 .

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Sadtler, K., Macisaac, C., Zepeda, F., Doloff, J., Langer, R. S., & Anderson, D. G. (2019). Apolipoproteins are a mediator of tissue-specificity in the foreign body response. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.