Apolipoprotein E polymorphism in the Greek population

Ekaterini Sklavounou, Effrosini Economou-Petersen, Georgia Karadima, Marios Panas, Dimitris Avramopoulos, Angeliki Varsou, Dimitris Vassilopoulos, Michael B. Petersen

Research output: Contribution to journalArticle

Abstract

The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world.

Original languageEnglish (US)
Pages (from-to)216-218
Number of pages3
JournalClinical Genetics
Volume52
Issue number4
StatePublished - Oct 1 1997

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Keywords

  • Apolipoprotein E
  • DNA polymorphism
  • Greek population
  • Population genetics

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Sklavounou, E., Economou-Petersen, E., Karadima, G., Panas, M., Avramopoulos, D., Varsou, A., Vassilopoulos, D., & Petersen, M. B. (1997). Apolipoprotein E polymorphism in the Greek population. Clinical Genetics, 52(4), 216-218.