Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians

Amy R. Borenstein; James A. Mortimer; Yougui Wu; Fern M. Jureidini-Webb; M. Daniele Fallin; Brent J. Small; Michael Mullan; Fiona C. Crawford

Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians

Amy R. Borenstein, James A. Mortimer, Yougui Wu, Fern M. Jureidini-Webb, M. Daniele Fallin, Brent J. Small, Michael Mullan, Fiona C. Crawford

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To compare relative frequencies of apolipoprotein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-ε4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-ε4 allele and any of the cognitive measures. Among Caucasians, APOE-ε4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-ε4 allele in our African-American sample compared to other US-based studies.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Ethnicity and Disease
Volume	16
Issue number	1
State	Published - 2006

Keywords

Apolipoproteins E
Cognition
Gene frequency
Racial groups

ASJC Scopus subject areas

Epidemiology

Cite this

@article{690b873bcc834326989737347e62362f,

title = "Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians",

abstract = "To compare relative frequencies of apolipoprotein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-ε4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-ε4 allele and any of the cognitive measures. Among Caucasians, APOE-ε4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-ε4 allele in our African-American sample compared to other US-based studies.",

keywords = "Apolipoproteins E, Cognition, Gene frequency, Racial groups",

author = "Borenstein, {Amy R.} and Mortimer, {James A.} and Yougui Wu and Jureidini-Webb, {Fern M.} and Fallin, {M. Daniele} and Small, {Brent J.} and Michael Mullan and Crawford, {Fiona C.}",

year = "2006",

language = "English (US)",

volume = "16",

pages = "9--15",

journal = "Ethnicity and Disease",

issn = "1049-510X",

publisher = "ISHIB",

number = "1",

}

TY - JOUR

T1 - Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians

AU - Borenstein, Amy R.

AU - Mortimer, James A.

AU - Wu, Yougui

AU - Jureidini-Webb, Fern M.

AU - Fallin, M. Daniele

AU - Small, Brent J.

AU - Mullan, Michael

AU - Crawford, Fiona C.

PY - 2006

Y1 - 2006

N2 - To compare relative frequencies of apolipoprotein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-ε4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-ε4 allele and any of the cognitive measures. Among Caucasians, APOE-ε4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-ε4 allele in our African-American sample compared to other US-based studies.

AB - To compare relative frequencies of apolipoprotein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-ε4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-ε4 allele and any of the cognitive measures. Among Caucasians, APOE-ε4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-ε4 allele in our African-American sample compared to other US-based studies.

KW - Apolipoproteins E

KW - Cognition

KW - Gene frequency

KW - Racial groups

UR - http://www.scopus.com/inward/record.url?scp=33744993649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744993649&partnerID=8YFLogxK

M3 - Article

C2 - 16599342

AN - SCOPUS:33744993649

SN - 1049-510X

VL - 16

SP - 9

EP - 15

JO - Ethnicity and Disease

JF - Ethnicity and Disease

IS - 1

ER -

Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this