Apolipoprotein E allele distribution in parents of Down's syndrome children

Dimitrios Avramopoulos, Margareta Mikkelsen, Dimitris Vassilopoulos, Maria Grigoriadou, Michael B. Petersen

Research output: Contribution to journalArticle

Abstract

Background. An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele ε4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their parents. Methods. We studied 188 Danish people with non-mosaic, free trisomy 21 of known parental origin (determined by DNA polymorphism analysis), and their parents, chosen from a population-based study of DS, and compared the frequency of apoE alleles with a previously published Danish control sample. Findings. In people with DS, there was no significant difference in apoE allele distribution compared with controls. The frequency of allele ε4 in the fathers (11.8%) was significantly lower than in controls (17.4%, p = 0.02). The frequency of allele ε4 in the mothers (19.4%) was not significantly different from that of controls. Nevertheless, in young mothers with a meiosis II error, ε4 frequency was 30.0%, significantly higher than in older mothers with a meiosis II error (13.0%, p = 0.03). Interpretation. We suggest that apoE allele ε4 is a risk factor for meiosis II non-disjunction in young mothers, but the biological role of apoE in oocytes remains to be investigated.

Original languageEnglish (US)
Pages (from-to)862-865
Number of pages4
JournalThe Lancet
Volume347
Issue number9005
DOIs
StatePublished - Mar 30 1996
Externally publishedYes

Fingerprint

Apolipoproteins E
Down Syndrome
Parents
Alleles
Mothers
Meiosis
Apolipoprotein E4
Gene Frequency
Alzheimer Disease
Genetic Predisposition to Disease
Fathers
Oocytes
DNA
Population
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Avramopoulos, D., Mikkelsen, M., Vassilopoulos, D., Grigoriadou, M., & Petersen, M. B. (1996). Apolipoprotein E allele distribution in parents of Down's syndrome children. The Lancet, 347(9005), 862-865. https://doi.org/10.1016/S0140-6736(96)91346-X

Apolipoprotein E allele distribution in parents of Down's syndrome children. / Avramopoulos, Dimitrios; Mikkelsen, Margareta; Vassilopoulos, Dimitris; Grigoriadou, Maria; Petersen, Michael B.

In: The Lancet, Vol. 347, No. 9005, 30.03.1996, p. 862-865.

Research output: Contribution to journalArticle

Avramopoulos, D, Mikkelsen, M, Vassilopoulos, D, Grigoriadou, M & Petersen, MB 1996, 'Apolipoprotein E allele distribution in parents of Down's syndrome children', The Lancet, vol. 347, no. 9005, pp. 862-865. https://doi.org/10.1016/S0140-6736(96)91346-X
Avramopoulos, Dimitrios ; Mikkelsen, Margareta ; Vassilopoulos, Dimitris ; Grigoriadou, Maria ; Petersen, Michael B. / Apolipoprotein E allele distribution in parents of Down's syndrome children. In: The Lancet. 1996 ; Vol. 347, No. 9005. pp. 862-865.
@article{a174203fde6b4ef08877dad832c10d66,
title = "Apolipoprotein E allele distribution in parents of Down's syndrome children",
abstract = "Background. An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele ε4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their parents. Methods. We studied 188 Danish people with non-mosaic, free trisomy 21 of known parental origin (determined by DNA polymorphism analysis), and their parents, chosen from a population-based study of DS, and compared the frequency of apoE alleles with a previously published Danish control sample. Findings. In people with DS, there was no significant difference in apoE allele distribution compared with controls. The frequency of allele ε4 in the fathers (11.8{\%}) was significantly lower than in controls (17.4{\%}, p = 0.02). The frequency of allele ε4 in the mothers (19.4{\%}) was not significantly different from that of controls. Nevertheless, in young mothers with a meiosis II error, ε4 frequency was 30.0{\%}, significantly higher than in older mothers with a meiosis II error (13.0{\%}, p = 0.03). Interpretation. We suggest that apoE allele ε4 is a risk factor for meiosis II non-disjunction in young mothers, but the biological role of apoE in oocytes remains to be investigated.",
author = "Dimitrios Avramopoulos and Margareta Mikkelsen and Dimitris Vassilopoulos and Maria Grigoriadou and Petersen, {Michael B.}",
year = "1996",
month = "3",
day = "30",
doi = "10.1016/S0140-6736(96)91346-X",
language = "English (US)",
volume = "347",
pages = "862--865",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9005",

}

TY - JOUR

T1 - Apolipoprotein E allele distribution in parents of Down's syndrome children

AU - Avramopoulos, Dimitrios

AU - Mikkelsen, Margareta

AU - Vassilopoulos, Dimitris

AU - Grigoriadou, Maria

AU - Petersen, Michael B.

PY - 1996/3/30

Y1 - 1996/3/30

N2 - Background. An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele ε4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their parents. Methods. We studied 188 Danish people with non-mosaic, free trisomy 21 of known parental origin (determined by DNA polymorphism analysis), and their parents, chosen from a population-based study of DS, and compared the frequency of apoE alleles with a previously published Danish control sample. Findings. In people with DS, there was no significant difference in apoE allele distribution compared with controls. The frequency of allele ε4 in the fathers (11.8%) was significantly lower than in controls (17.4%, p = 0.02). The frequency of allele ε4 in the mothers (19.4%) was not significantly different from that of controls. Nevertheless, in young mothers with a meiosis II error, ε4 frequency was 30.0%, significantly higher than in older mothers with a meiosis II error (13.0%, p = 0.03). Interpretation. We suggest that apoE allele ε4 is a risk factor for meiosis II non-disjunction in young mothers, but the biological role of apoE in oocytes remains to be investigated.

AB - Background. An increased risk of Alzheimer's disease (AD) has been reported in young mothers of Down's syndrome (DS) probands. Allele ε4 of the apolipoprotein E (apoE) gene is a genetic susceptibility factor for AD. We examined the distribution of apoE alleles in people with DS and their parents. Methods. We studied 188 Danish people with non-mosaic, free trisomy 21 of known parental origin (determined by DNA polymorphism analysis), and their parents, chosen from a population-based study of DS, and compared the frequency of apoE alleles with a previously published Danish control sample. Findings. In people with DS, there was no significant difference in apoE allele distribution compared with controls. The frequency of allele ε4 in the fathers (11.8%) was significantly lower than in controls (17.4%, p = 0.02). The frequency of allele ε4 in the mothers (19.4%) was not significantly different from that of controls. Nevertheless, in young mothers with a meiosis II error, ε4 frequency was 30.0%, significantly higher than in older mothers with a meiosis II error (13.0%, p = 0.03). Interpretation. We suggest that apoE allele ε4 is a risk factor for meiosis II non-disjunction in young mothers, but the biological role of apoE in oocytes remains to be investigated.

UR - http://www.scopus.com/inward/record.url?scp=0030010225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030010225&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(96)91346-X

DO - 10.1016/S0140-6736(96)91346-X

M3 - Article

C2 - 8622392

AN - SCOPUS:0030010225

VL - 347

SP - 862

EP - 865

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9005

ER -