Apolipoprotein e allele and hearing thresholds in older adults

David J. Mener, Joshua Betz, Kristine Yaffe, Tamara B. Harris, Elizabeth P. Helzner, Suzanne Satterfield, Denise K. Houston, Elsa S. Strotmeyer, Sheila R. Pratt, Eleanor M. Simonsick, Frank R. Lin

Research output: Contribution to journalArticlepeer-review


Background: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. Methods: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. Results: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P =.013) and 8.0 kHz (β = -3.05 kHz, P =.006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P =.021). Conclusion: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Issue number1
StatePublished - Feb 1 2016


  • aging
  • apolipoprotein E
  • cognition
  • dementia
  • hearing loss
  • hearing thresholds

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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