Apolipoprotein E ε4 allele and hippocampal volume in twins with normal cognition

B. L. Plassman, K. A. Welsh-Bohmer, E. D. Bigler, M. A. Johnson, C. V. Anderson, M. J. Helms, A. M. Saunders, J. C.S. Breitner

Research output: Contribution to journalArticlepeer-review


We examined the relation of APOE-ε4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an ε4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the ε4 group compared to the group without ε4. Combined with prior reports, these findings suggest that ε4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.

Original languageEnglish (US)
Pages (from-to)985-989
Number of pages5
Issue number4
StatePublished - Apr 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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