Apolipoprotein E ε2 allele and risk of stroke in the older population

Luigi Ferrucci; Jack M. Guralnik; Marco Pahor; Tamara Harris; Maria Chiara Corti; Brad T. Hyman; Robert B. Wallace; Richard J. Havlik

Apolipoprotein E ε2 allele and risk of stroke in the older population

Luigi Ferrucci, Jack M. Guralnik, Marco Pahor, Tamara Harris, Maria Chiara Corti, Brad T. Hyman, Robert B. Wallace, Richard J. Havlik

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Background and Purpose: There is evidence for a role of apolipoprotein E (apoE) in atherosclerosis. Coronary heart disease morbidity is higher in persons carrying an ε4 allele and lower in those carrying an ε2 allele, but the effect on cerebrovascular disease is controversial. We estimated the risk of stroke associated with different apoE genotypes in older persons. Methods: At the sixth annual follow-up of the Iowa cohort of the Established Populations for Epidemiologic Studies of the Elderly, 1664 persons aged ≤71 years and free of stroke were genotyped for apo E. Occurrence of ischemic strokes was prospectively assessed from subsequent hospital discharge records and death certificates. Results: One hundred fifty persons had an ischemic stroke over the subsequent 5 years (21.2 per 1000 person-years). The presence of ε3 and ε4 did not influence stroke risk. Among persons aged

Original language	English (US)
Pages (from-to)	2410-2416
Number of pages	7
Journal	Stroke
Volume	28
Issue number	12
State	Published - Dec 1997
Externally published	Yes

Keywords

Aging
Apolipoproteins
Risk factors
Stroke

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
General Neuroscience

Cite this

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title = "Apolipoprotein E ε2 allele and risk of stroke in the older population",

abstract = "Background and Purpose: There is evidence for a role of apolipoprotein E (apoE) in atherosclerosis. Coronary heart disease morbidity is higher in persons carrying an ε4 allele and lower in those carrying an ε2 allele, but the effect on cerebrovascular disease is controversial. We estimated the risk of stroke associated with different apoE genotypes in older persons. Methods: At the sixth annual follow-up of the Iowa cohort of the Established Populations for Epidemiologic Studies of the Elderly, 1664 persons aged ≤71 years and free of stroke were genotyped for apo E. Occurrence of ischemic strokes was prospectively assessed from subsequent hospital discharge records and death certificates. Results: One hundred fifty persons had an ischemic stroke over the subsequent 5 years (21.2 per 1000 person-years). The presence of ε3 and ε4 did not influence stroke risk. Among persons aged ",

keywords = "Aging, Apolipoproteins, Risk factors, Stroke",

author = "Luigi Ferrucci and Guralnik, {Jack M.} and Marco Pahor and Tamara Harris and Corti, {Maria Chiara} and Hyman, {Brad T.} and Wallace, {Robert B.} and Havlik, {Richard J.}",

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TY - JOUR

T1 - Apolipoprotein E ε2 allele and risk of stroke in the older population

AU - Ferrucci, Luigi

AU - Guralnik, Jack M.

AU - Pahor, Marco

AU - Harris, Tamara

AU - Corti, Maria Chiara

AU - Hyman, Brad T.

AU - Wallace, Robert B.

AU - Havlik, Richard J.

PY - 1997/12

Y1 - 1997/12

N2 - Background and Purpose: There is evidence for a role of apolipoprotein E (apoE) in atherosclerosis. Coronary heart disease morbidity is higher in persons carrying an ε4 allele and lower in those carrying an ε2 allele, but the effect on cerebrovascular disease is controversial. We estimated the risk of stroke associated with different apoE genotypes in older persons. Methods: At the sixth annual follow-up of the Iowa cohort of the Established Populations for Epidemiologic Studies of the Elderly, 1664 persons aged ≤71 years and free of stroke were genotyped for apo E. Occurrence of ischemic strokes was prospectively assessed from subsequent hospital discharge records and death certificates. Results: One hundred fifty persons had an ischemic stroke over the subsequent 5 years (21.2 per 1000 person-years). The presence of ε3 and ε4 did not influence stroke risk. Among persons aged

AB - Background and Purpose: There is evidence for a role of apolipoprotein E (apoE) in atherosclerosis. Coronary heart disease morbidity is higher in persons carrying an ε4 allele and lower in those carrying an ε2 allele, but the effect on cerebrovascular disease is controversial. We estimated the risk of stroke associated with different apoE genotypes in older persons. Methods: At the sixth annual follow-up of the Iowa cohort of the Established Populations for Epidemiologic Studies of the Elderly, 1664 persons aged ≤71 years and free of stroke were genotyped for apo E. Occurrence of ischemic strokes was prospectively assessed from subsequent hospital discharge records and death certificates. Results: One hundred fifty persons had an ischemic stroke over the subsequent 5 years (21.2 per 1000 person-years). The presence of ε3 and ε4 did not influence stroke risk. Among persons aged

KW - Aging

KW - Apolipoproteins

KW - Risk factors

KW - Stroke

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Apolipoprotein E ε2 allele and risk of stroke in the older population

Abstract

Keywords

ASJC Scopus subject areas

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