Apolipoprotein E ε4 allele and hippocampal volume in twins with normal cognition

B. L. Plassman; K. A. Welsh-Bohmer; E. D. Bigler; M. A. Johnson; C. V. Anderson; M. J. Helms; A. M. Saunders; J. C.S. Breitner

doi:10.1212/wnl.48.4.985

Apolipoprotein E ε4 allele and hippocampal volume in twins with normal cognition

B. L. Plassman, K. A. Welsh-Bohmer, E. D. Bigler, M. A. Johnson, C. V. Anderson, M. J. Helms, A. M. Saunders, J. C.S. Breitner

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Abstract

We examined the relation of APOE-ε4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an ε4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the ε4 group compared to the group without ε4. Combined with prior reports, these findings suggest that ε4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.

Original language	English (US)
Pages (from-to)	985-989
Number of pages	5
Journal	Neurology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1212/wnl.48.4.985
State	Published - Apr 1997
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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abstract = "We examined the relation of APOE-ε4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an ε4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the ε4 group compared to the group without ε4. Combined with prior reports, these findings suggest that ε4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.",

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AU - Plassman, B. L.

AU - Welsh-Bohmer, K. A.

AU - Bigler, E. D.

AU - Johnson, M. A.

AU - Anderson, C. V.

AU - Helms, M. J.

AU - Saunders, A. M.

AU - Breitner, J. C.S.

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AB - We examined the relation of APOE-ε4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the groups categorized by the presence of an ε4 allele. However, the mean normalized right and left hippocampal volumes were smaller in the ε4 group compared to the group without ε4. Combined with prior reports, these findings suggest that ε4 is associated with differences in brain morphology that may be evident when no symptoms of dementia are present.

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Apolipoprotein E ε4 allele and hippocampal volume in twins with normal cognition

Abstract

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