Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms

Y. Ma, J. A A Ladias, R. Butler, V. N. Schumaker, S. E. Antonarakis, A. J. Lusis, C. Heinzman, P. O. Kwiterovich

Research output: Contribution to journalArticle

Abstract

Berg et al. (Clin Genet 1986;30:515-520) have reported that an Xba I DNA polymorphic site in exon 26 of the apolipoprotein (apo) B gene is associated both with the Ag(x/y) immunochemical polymorphism and with elevated serum lipoprotein levels. Ma et al. (Arteriosclerosis 1987;7:301-305) have reported that the same Xba I polymorphism is associated with a different immunochemical polymorphism Ag(c/g). To extend and clarify these observations, we have determined the Ag and Xba I polymorphism for 106 individuals. We find that the Xba I restriction fragment length polymorphism is in linkage disequilibrium with both Ag(x/y) and Ag(c/g) loci; thus, all 31 Xba I(X1/X1) genotypes observed in this study are also Ag(y/y). All but one of 22 Xba I(X2/X2) genotypes are also Ag(g/g). For individualse homozygous at either two or three of these loci, it was possible to determine the haplotypes for 128 apo B alleles. Of the eight possible apo B haplotypes, only four were represented in this unambiguous subpopulation, although other minor haplotypes were present in the total population from which it was derived. The identification of major apo B haplotypes in human populations may simplify the search for significant correlations between certain apo B alleles and lipid levels and atherosclerosis.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalArteriosclerosis
Volume8
Issue number5
StatePublished - 1988
Externally publishedYes

Fingerprint

Apolipoproteins B
Haplotypes
DNA
Genes
Alleles
Genotype
Viverridae
Arteriosclerosis
Linkage Disequilibrium
Restriction Fragment Length Polymorphisms
Population
Lipoproteins
Exons
Atherosclerosis
Lipids
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ma, Y., Ladias, J. A. A., Butler, R., Schumaker, V. N., Antonarakis, S. E., Lusis, A. J., ... Kwiterovich, P. O. (1988). Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms. Arteriosclerosis, 8(5), 521-524.

Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms. / Ma, Y.; Ladias, J. A A; Butler, R.; Schumaker, V. N.; Antonarakis, S. E.; Lusis, A. J.; Heinzman, C.; Kwiterovich, P. O.

In: Arteriosclerosis, Vol. 8, No. 5, 1988, p. 521-524.

Research output: Contribution to journalArticle

Ma, Y, Ladias, JAA, Butler, R, Schumaker, VN, Antonarakis, SE, Lusis, AJ, Heinzman, C & Kwiterovich, PO 1988, 'Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms', Arteriosclerosis, vol. 8, no. 5, pp. 521-524.
Ma Y, Ladias JAA, Butler R, Schumaker VN, Antonarakis SE, Lusis AJ et al. Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms. Arteriosclerosis. 1988;8(5):521-524.
Ma, Y. ; Ladias, J. A A ; Butler, R. ; Schumaker, V. N. ; Antonarakis, S. E. ; Lusis, A. J. ; Heinzman, C. ; Kwiterovich, P. O. / Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms. In: Arteriosclerosis. 1988 ; Vol. 8, No. 5. pp. 521-524.
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