APOL1 variants associate with increased risk of CKD among African Americans

Meredith C. Foster, Josef Coresh, Myriam Fornage, Brad C. Astor, Morgan Grams, Nora Franceschini, Eric Boerwinkle, Rulan S. Parekh, W. H.L. Kao

Research output: Contribution to journalArticlepeer-review

Abstract

Although case-control studies suggest that African Americans with common coding variants in the APOL1 gene are 5-29 timesmore likely than those individuals without such variants to have focal segmental glomerulosclerosis, HIV-associated nephropathy, or ESRD, prospective studies have not yet evaluated the impact of these variants on CKD in a community-based sample of African Americans. Here, we studied whether the APOL1 G1 and G2 risk alleles associate with the development of CKD and progression to ESRD by analyzing data from3067 African Americans in the Atherosclerosis Risk in Communities Study who did not have CKD at baseline.Carryingtwo risk alleles associatedwith a 1.49-fold increased risk ofCKD(95%CI=1.02 to 2.17) and a 1.88-fold increased risk of ESRD (95% CI=1.20 to 2.93) compared with zero or one risk allele; associations persisted after adjusting for European ancestry. Among participants who developed CKD, those participants with two risk alleles were more likely to progress to ESRD than their counterparts with zero or one risk allele (HR=2.22, 95% CI=1.01 to 4.84). In conclusion, APOL1 risk variants are risk factors for the development of CKD and progression from CKD to ESRD among African Americans in the general population.

Original languageEnglish (US)
Pages (from-to)1484-1491
Number of pages8
JournalJournal of the American Society of Nephrology
Volume24
Issue number9
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'APOL1 variants associate with increased risk of CKD among African Americans'. Together they form a unique fingerprint.

Cite this