TY - JOUR
T1 - APOL1 risk variants and death among African American hemodialysis patients
T2 - survival of the fittest?
AU - Chen, Teresa K.
AU - Estrella, Michelle M.
N1 - Funding Information:
TKC receives support through the Norman S. Coplon Extramural Grant Program by Satellite Healthcare, a not-for-profit renal care provider. MME receives support through National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases grant R01DK103574.
Publisher Copyright:
© 2016 International Society of Nephrology
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Recent studies have focused on associations of the APOL1 risk variants with outcomes beyond kidney disease, including cardiovascular disease and mortality. Ma and colleagues now expand on this growing but contradicting body of work. Their analysis of a prevalent cohort of African American hemodialysis patients shows that the risk variants are associated with a survival benefit among nondiabetics. Whether this simply reflects a healthier status at hemodialysis initiation among those carrying 2 risk variants or whether these variants truly confer a survival advantage is unclear.
AB - Recent studies have focused on associations of the APOL1 risk variants with outcomes beyond kidney disease, including cardiovascular disease and mortality. Ma and colleagues now expand on this growing but contradicting body of work. Their analysis of a prevalent cohort of African American hemodialysis patients shows that the risk variants are associated with a survival benefit among nondiabetics. Whether this simply reflects a healthier status at hemodialysis initiation among those carrying 2 risk variants or whether these variants truly confer a survival advantage is unclear.
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U2 - 10.1016/j.kint.2016.03.024
DO - 10.1016/j.kint.2016.03.024
M3 - Comment/debate
C2 - 27418089
AN - SCOPUS:84992504771
SN - 0085-2538
VL - 90
SP - 249
EP - 252
JO - Kidney international
JF - Kidney international
IS - 2
ER -