ApoE4 allele is associated with late-life depression: A population-based study

Yung Chieh Yen, George Rebok, Joseph J Gallo, Ming Jen Yang, For Wey Lung, Chun Hua Shih

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: This study aimed to clarify the relationship between the ε4 allele and late-life depression, taking into account lipid profile, vascular diseases, and sociodemographics. METHODS: Using a multilevel stratified random sampling strategy, a total of 500 subjects aged 65 to 74 years were recruited for this cross-sectional study from the official household records of an entire county in southern Taiwan. Depressive symptoms were assessed by the Taiwanese Depression Questionnaire (TDQ). Cognitive function was assessed by the Short Portable Mental Status Questionnaire. Blood samples were collected for the determination of the apolipoprotein E (ApoE) polymorphism and the lipid profile. RESULTS: A total of 283 subjects (58.7% male, with a mean age of 69.2 ± 2.7 years) completed all questionnaires and collection of blood samples. Using the Χ 2 test, the overall difference for frequency of the presence of the ε4 allele was significant among the severe group (TDQ score >18), moderate group (TDQ score 9-18), and mild group (TDQ score

Original languageEnglish (US)
Pages (from-to)858-868
Number of pages11
JournalAmerican Journal of Geriatric Psychiatry
Volume15
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Apolipoprotein E4
Alleles
Depression
Population
Lipids
Apolipoproteins E
Taiwan
Vascular Diseases
Cognition
Surveys and Questionnaires
Cross-Sectional Studies

Keywords

  • Apolipoprotein E allele
  • cholesterol
  • depression
  • elder
  • hypothesis
  • latent class regression
  • Taiwanese Depression Questionnaire
  • vascular depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

ApoE4 allele is associated with late-life depression : A population-based study. / Yen, Yung Chieh; Rebok, George; Gallo, Joseph J; Yang, Ming Jen; Lung, For Wey; Shih, Chun Hua.

In: American Journal of Geriatric Psychiatry, Vol. 15, No. 10, 10.2007, p. 858-868.

Research output: Contribution to journalArticle

Yen, Yung Chieh ; Rebok, George ; Gallo, Joseph J ; Yang, Ming Jen ; Lung, For Wey ; Shih, Chun Hua. / ApoE4 allele is associated with late-life depression : A population-based study. In: American Journal of Geriatric Psychiatry. 2007 ; Vol. 15, No. 10. pp. 858-868.
@article{0d6fc870a1ac4536811be1167f0bab46,
title = "ApoE4 allele is associated with late-life depression: A population-based study",
abstract = "OBJECTIVE: This study aimed to clarify the relationship between the ε4 allele and late-life depression, taking into account lipid profile, vascular diseases, and sociodemographics. METHODS: Using a multilevel stratified random sampling strategy, a total of 500 subjects aged 65 to 74 years were recruited for this cross-sectional study from the official household records of an entire county in southern Taiwan. Depressive symptoms were assessed by the Taiwanese Depression Questionnaire (TDQ). Cognitive function was assessed by the Short Portable Mental Status Questionnaire. Blood samples were collected for the determination of the apolipoprotein E (ApoE) polymorphism and the lipid profile. RESULTS: A total of 283 subjects (58.7{\%} male, with a mean age of 69.2 ± 2.7 years) completed all questionnaires and collection of blood samples. Using the Χ 2 test, the overall difference for frequency of the presence of the ε4 allele was significant among the severe group (TDQ score >18), moderate group (TDQ score 9-18), and mild group (TDQ score",
keywords = "Apolipoprotein E allele, cholesterol, depression, elder, hypothesis, latent class regression, Taiwanese Depression Questionnaire, vascular depression",
author = "Yen, {Yung Chieh} and George Rebok and Gallo, {Joseph J} and Yang, {Ming Jen} and Lung, {For Wey} and Shih, {Chun Hua}",
year = "2007",
month = "10",
doi = "10.1097/JGP.0b013e3180f63373",
language = "English (US)",
volume = "15",
pages = "858--868",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - ApoE4 allele is associated with late-life depression

T2 - A population-based study

AU - Yen, Yung Chieh

AU - Rebok, George

AU - Gallo, Joseph J

AU - Yang, Ming Jen

AU - Lung, For Wey

AU - Shih, Chun Hua

PY - 2007/10

Y1 - 2007/10

N2 - OBJECTIVE: This study aimed to clarify the relationship between the ε4 allele and late-life depression, taking into account lipid profile, vascular diseases, and sociodemographics. METHODS: Using a multilevel stratified random sampling strategy, a total of 500 subjects aged 65 to 74 years were recruited for this cross-sectional study from the official household records of an entire county in southern Taiwan. Depressive symptoms were assessed by the Taiwanese Depression Questionnaire (TDQ). Cognitive function was assessed by the Short Portable Mental Status Questionnaire. Blood samples were collected for the determination of the apolipoprotein E (ApoE) polymorphism and the lipid profile. RESULTS: A total of 283 subjects (58.7% male, with a mean age of 69.2 ± 2.7 years) completed all questionnaires and collection of blood samples. Using the Χ 2 test, the overall difference for frequency of the presence of the ε4 allele was significant among the severe group (TDQ score >18), moderate group (TDQ score 9-18), and mild group (TDQ score

AB - OBJECTIVE: This study aimed to clarify the relationship between the ε4 allele and late-life depression, taking into account lipid profile, vascular diseases, and sociodemographics. METHODS: Using a multilevel stratified random sampling strategy, a total of 500 subjects aged 65 to 74 years were recruited for this cross-sectional study from the official household records of an entire county in southern Taiwan. Depressive symptoms were assessed by the Taiwanese Depression Questionnaire (TDQ). Cognitive function was assessed by the Short Portable Mental Status Questionnaire. Blood samples were collected for the determination of the apolipoprotein E (ApoE) polymorphism and the lipid profile. RESULTS: A total of 283 subjects (58.7% male, with a mean age of 69.2 ± 2.7 years) completed all questionnaires and collection of blood samples. Using the Χ 2 test, the overall difference for frequency of the presence of the ε4 allele was significant among the severe group (TDQ score >18), moderate group (TDQ score 9-18), and mild group (TDQ score

KW - Apolipoprotein E allele

KW - cholesterol

KW - depression

KW - elder

KW - hypothesis

KW - latent class regression

KW - Taiwanese Depression Questionnaire

KW - vascular depression

UR - http://www.scopus.com/inward/record.url?scp=38449113372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449113372&partnerID=8YFLogxK

U2 - 10.1097/JGP.0b013e3180f63373

DO - 10.1097/JGP.0b013e3180f63373

M3 - Article

C2 - 17911363

AN - SCOPUS:38449113372

VL - 15

SP - 858

EP - 868

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

IS - 10

ER -