APOE ε4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy

Z. Zhou, A. Hoke, D. R. Cornblath, J. W. Griffin, M. Polydefkis

Research output: Contribution to journalArticle


The presence of an APOE ε4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE ε4 in patients presenting with sensory predominant neuropathy. APOE ε4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance-associated neuropathy was 16 to 17%, and not different from patients with idiopathic neuropathy (17%) or published normative values (16%). APOE ε4 may not function as a susceptibility gene in sensory predominant neuropathy.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
Issue number1
StatePublished - Jan 11 2005


ASJC Scopus subject areas

  • Clinical Neurology

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