@article{7621f5976eb341be8febb68f1b36757e,
title = "Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes",
abstract = "Cone, but not rod, pigments can dissociate in darkness into apo-opsin and chromophore without isomerization, but this cone pigment property has been generally overlooked. Luo et al. report experiments showing that the dark apo-opsin content especially in L cones is substantial, producing dark noise that may constrain cone photodetection threshold.",
keywords = "cone photodetection threshold, cone phototransduction, constitutive apo-opsin activity, dark noise, truncated-cone recording",
author = "Donggen Luo and Daniel Silverman and Rikard Frederiksen and Rajan Adhikari and Cao, {Li Hui} and Oatis, {John E.} and Masahiro Kono and Cornwall, {M. Carter} and Yau, {King Wai}",
note = "Funding Information: We thank Wendy Yue, Zuying Chai, Michael Tri Do, and Rongchang Li for comments. This work was supported by grant R01 EY06837 ( National Eye Institute , United States; K.-W.Y.) and R01 EY01157 (M.C.C.); the Antὀnio Champalimaud Vision Award ( Champalimaud Foundation, Portugal ); and the Beckman-Argyros Award in Vision Research ( Arnold and Mabel Beckman Foundation , United States), both to K.-W.Y., as well as the Visual Science Training Program Fellowship, EY007143 ( National Eye Institute , United States), to D.S. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = dec,
day = "21",
doi = "10.1016/j.cub.2020.09.062",
language = "English (US)",
volume = "30",
pages = "4921--4931.e5",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "24",
}