Apo E genotype, diabetes, and peripheral arterial disease in older men: The Honolulu Asia-aging study

Helaine E. Resnick, Beatriz Rodriguez, Richard Havlik, Luigi Ferrucci, Daniel Foley, J. David Curb, Tamara B. Harris

Research output: Contribution to journalArticlepeer-review

Abstract

The ε4 allele of the gene coding for apolipoprotein (apo) E is associated with an atherogenic lipid profile that has been linked to increased risk of coronary artery disease (CAD). Apo E genotype may also be associated with peripheral arterial disease (PAD). If present, this association may be modified by diabetes, which is also associated with dyslipidemia that predisposes to macrovascular disease. Observable associations between both ApoE genotype and diabetes with PAD may be confounded by smoking, a potent PAD risk factor that is unrelated to lipids. From 1991 to 1993, apo E genotypes (2/3, 3/3, 3/4), PAD (defined as ankle- brachial index [ABI]

Original languageEnglish (US)
Pages (from-to)52-63
Number of pages12
JournalGenetic Epidemiology
Volume19
Issue number1
DOIs
StatePublished - Jul 2000
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Diabetes
  • Elderly
  • Men
  • Peripheral arterial disease
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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