Apo E genotype, diabetes, and peripheral arterial disease in older men: The Honolulu Asia-aging study

Helaine E. Resnick; Beatriz Rodriguez; Richard Havlik; Luigi Ferrucci; Daniel Foley; J. David Curb; Tamara B. Harris

doi:10.1002/1098-2272(200007)19:1<52::AID-GEPI4>3.0.CO;2-M

Apo E genotype, diabetes, and peripheral arterial disease in older men: The Honolulu Asia-aging study

Helaine E. Resnick, Beatriz Rodriguez, Richard Havlik, Luigi Ferrucci, Daniel Foley, J. David Curb, Tamara B. Harris

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The ε4 allele of the gene coding for apolipoprotein (apo) E is associated with an atherogenic lipid profile that has been linked to increased risk of coronary artery disease (CAD). Apo E genotype may also be associated with peripheral arterial disease (PAD). If present, this association may be modified by diabetes, which is also associated with dyslipidemia that predisposes to macrovascular disease. Observable associations between both ApoE genotype and diabetes with PAD may be confounded by smoking, a potent PAD risk factor that is unrelated to lipids. From 1991 to 1993, apo E genotypes (2/3, 3/3, 3/4), PAD (defined as ankle- brachial index [ABI]

Original language	English (US)
Pages (from-to)	52-63
Number of pages	12
Journal	Genetic Epidemiology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1002/1098-2272(200007)19:1<52::AID-GEPI4>3.0.CO;2-M
State	Published - Jul 2000
Externally published	Yes

Keywords

Apolipoprotein E
Diabetes
Elderly
Men
Peripheral arterial disease
Smoking

ASJC Scopus subject areas

Genetics(clinical)
Epidemiology

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10.1002/1098-2272(200007)19:1<52::AID-GEPI4>3.0.CO;2-M

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title = "Apo E genotype, diabetes, and peripheral arterial disease in older men: The Honolulu Asia-aging study",

abstract = "The ε4 allele of the gene coding for apolipoprotein (apo) E is associated with an atherogenic lipid profile that has been linked to increased risk of coronary artery disease (CAD). Apo E genotype may also be associated with peripheral arterial disease (PAD). If present, this association may be modified by diabetes, which is also associated with dyslipidemia that predisposes to macrovascular disease. Observable associations between both ApoE genotype and diabetes with PAD may be confounded by smoking, a potent PAD risk factor that is unrelated to lipids. From 1991 to 1993, apo E genotypes (2/3, 3/3, 3/4), PAD (defined as ankle- brachial index [ABI] ",

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AU - Havlik, Richard

AU - Ferrucci, Luigi

AU - Foley, Daniel

AU - Curb, J. David

AU - Harris, Tamara B.

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Apo E genotype, diabetes, and peripheral arterial disease in older men: The Honolulu Asia-aging study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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