Apathy is related to cognitive control and striatum volumes in prodromal huntington's disease

Maria B. Misiura, Jennifer Ciarochi, Jatin Vaidya, Jeremy Bockholt, Hans J. Johnson, Vince Daniel Calhoun, Jane S. Paulsen, Jessica A. Turner

Research output: Contribution to journalArticle

Abstract

Objectives: Apathy is a debilitating symptom of Huntington's disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington's disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to apathy. Methods: We constructed linear mixed models to analyze striatum volumes and cognitive control, a composite measure that includes tasks assessing with apathy scores from 797 prHD participants. The outcome variable for each model was apathy, and the independent variables for the four separate models were caudate volume, putamen volume, cognitive control score, and motor symptom score. We also included depression as a covariate to ensure that our results were not solely related to mood. Results: Caudate and putamen volumes, as well as measures of cognitive control, were significantly related to apathy scores even after controlling for depression. Conclusions: The behavioral apathy expressed by these individuals was related to regions of the brain commonly associated with isolated apathy, and not a direct result of mood symptoms. (JINS, 2019, 00, 1-8)

Original languageEnglish (US)
JournalJournal of the International Neuropsychological Society
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Apathy
Huntington Disease
Putamen
Depression
Inborn Genetic Diseases
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases
Psychiatry
Linear Models

Keywords

  • Apathy
  • Basal ganglia diseases
  • Caudate
  • Executive function
  • Huntington disease
  • Putamen

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Apathy is related to cognitive control and striatum volumes in prodromal huntington's disease. / Misiura, Maria B.; Ciarochi, Jennifer; Vaidya, Jatin; Bockholt, Jeremy; Johnson, Hans J.; Calhoun, Vince Daniel; Paulsen, Jane S.; Turner, Jessica A.

In: Journal of the International Neuropsychological Society, 01.01.2019.

Research output: Contribution to journalArticle

Misiura, Maria B. ; Ciarochi, Jennifer ; Vaidya, Jatin ; Bockholt, Jeremy ; Johnson, Hans J. ; Calhoun, Vince Daniel ; Paulsen, Jane S. ; Turner, Jessica A. / Apathy is related to cognitive control and striatum volumes in prodromal huntington's disease. In: Journal of the International Neuropsychological Society. 2019.
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