Abstract
Apathy, indifference, loss of initiative, or disinhibition (without concurrent sedation or hypomania) were observed among five patients receiving the serotonin reuptake blocking antidepressants fluvoxamine or fluoxetine. These effects appeared to be dose related. They disappeared rapidly when the dose of fluvoxamine, which has a short half-life, was reduced. Fiuoxetine, which has a long half-life, was more difficult to titrate. A possible relationship between mild drug-induced indifference and the therapeutic effects of serotonin reuptake blocking medication in anxiety disorders is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-345 |
| Number of pages | 3 |
| Journal | Journal of Clinical Psychopharmacology |
| Volume | 10 |
| Issue number | 5 |
| State | Published - 1990 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Psychiatry and Mental health
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Apathy and indifference in patients on fluvoxamine and fluoxetine. / Hoehn-Saric, Rudolf; Lipsey, John R; McLeod, Daniel R.
In: Journal of Clinical Psychopharmacology, Vol. 10, No. 5, 1990, p. 343-345.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apathy and indifference in patients on fluvoxamine and fluoxetine
AU - Hoehn-Saric, Rudolf
AU - Lipsey, John R
AU - McLeod, Daniel R.
PY - 1990
Y1 - 1990
N2 - Apathy, indifference, loss of initiative, or disinhibition (without concurrent sedation or hypomania) were observed among five patients receiving the serotonin reuptake blocking antidepressants fluvoxamine or fluoxetine. These effects appeared to be dose related. They disappeared rapidly when the dose of fluvoxamine, which has a short half-life, was reduced. Fiuoxetine, which has a long half-life, was more difficult to titrate. A possible relationship between mild drug-induced indifference and the therapeutic effects of serotonin reuptake blocking medication in anxiety disorders is discussed.
AB - Apathy, indifference, loss of initiative, or disinhibition (without concurrent sedation or hypomania) were observed among five patients receiving the serotonin reuptake blocking antidepressants fluvoxamine or fluoxetine. These effects appeared to be dose related. They disappeared rapidly when the dose of fluvoxamine, which has a short half-life, was reduced. Fiuoxetine, which has a long half-life, was more difficult to titrate. A possible relationship between mild drug-induced indifference and the therapeutic effects of serotonin reuptake blocking medication in anxiety disorders is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0025027698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025027698&partnerID=8YFLogxK
M3 - Article
C2 - 2124218
AN - SCOPUS:0025027698
VL - 10
SP - 343
EP - 345
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
SN - 0271-0749
IS - 5
ER -