Apathy and indifference in patients on fluvoxamine and fluoxetine

Research output: Contribution to journalArticle

Abstract

Apathy, indifference, loss of initiative, or disinhibition (without concurrent sedation or hypomania) were observed among five patients receiving the serotonin reuptake blocking antidepressants fluvoxamine or fluoxetine. These effects appeared to be dose related. They disappeared rapidly when the dose of fluvoxamine, which has a short half-life, was reduced. Fiuoxetine, which has a long half-life, was more difficult to titrate. A possible relationship between mild drug-induced indifference and the therapeutic effects of serotonin reuptake blocking medication in anxiety disorders is discussed.

Original languageEnglish (US)
Pages (from-to)343-345
Number of pages3
JournalJournal of Clinical Psychopharmacology
Volume10
Issue number5
StatePublished - 1990

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Fluvoxamine
Apathy
Fluoxetine
Half-Life
Serotonin
Therapeutic Uses
Anxiety Disorders
Antidepressive Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Apathy and indifference in patients on fluvoxamine and fluoxetine. / Hoehn-Saric, Rudolf; Lipsey, John R; McLeod, Daniel R.

In: Journal of Clinical Psychopharmacology, Vol. 10, No. 5, 1990, p. 343-345.

Research output: Contribution to journalArticle

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