Aortic plaque regression as determined by magnetic resonance imaging with high-dose and low-dose statin therapy

Ilan Gottlieb, Sachin Agarwal, Sandeep Gautam, Milind Desai, Henning Steen, William P. Warren, Sérgio Salles Xavier, João Ac Lima

Research output: Contribution to journalArticle

Abstract

Objective: We sought to compare the effects of high-dose with low-dose simvastatin therapy on aortic plaque morphology using transoesophageal magnetic resonance imaging (TEMRI). METHODS: Thirty-one patients with established moderate-to-severe atherosclerosis were recruited and randomized to 80 versus 20 mg/day simvastatin therapy. Aortic vessel wall and lumen volumes and areas were measured by TEMRI at baseline and 12 months. RESULTS: Significant differences were observed between the low-dose and high-dose statin therapy in reduction of low-density lipoprotein cholesterol (LDL-c) (10 mg/dl, P = 0.001), total cholesterol (16.2 mg/dl, P < 0.001), vessel wall area (19.0 mm, P < 0.001) and volume (343.4 mm, P < 0.001), as well as increase in lumen area (54.4 mm, P < 0.001) and volume (1038 mm, P < 0.001). LDL-c lowering was significantly associated with aortic wall area and volume reduction in both groups. CONCLUSION: High-dose statin leads to greater LDL-c reduction, aortic vessel wall reduction and lumen increase than low-dose statin therapy in patients with at least moderate-documented atherosclerosis.

Original languageEnglish (US)
Pages (from-to)700-706
Number of pages7
JournalJournal of cardiovascular medicine (Hagerstown, Md.)
Volume9
Issue number7
DOIs
StatePublished - Jul 2008

Keywords

  • Adverse cardiovascular events
  • Aorta
  • Atherosclerosis
  • Magnetic resonance imaging
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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