TY - JOUR
T1 - Aortic plaque regression as determined by magnetic resonance imaging with high-dose and low-dose statin therapy
AU - Gottlieb, Ilan
AU - Agarwal, Sachin
AU - Gautam, Sandeep
AU - Desai, Milind
AU - Steen, Henning
AU - Warren, William P.
AU - Xavier, Sérgio Salles
AU - Lima, João Ac
PY - 2008/7
Y1 - 2008/7
N2 - Objective: We sought to compare the effects of high-dose with low-dose simvastatin therapy on aortic plaque morphology using transoesophageal magnetic resonance imaging (TEMRI). METHODS: Thirty-one patients with established moderate-to-severe atherosclerosis were recruited and randomized to 80 versus 20 mg/day simvastatin therapy. Aortic vessel wall and lumen volumes and areas were measured by TEMRI at baseline and 12 months. RESULTS: Significant differences were observed between the low-dose and high-dose statin therapy in reduction of low-density lipoprotein cholesterol (LDL-c) (10 mg/dl, P = 0.001), total cholesterol (16.2 mg/dl, P < 0.001), vessel wall area (19.0 mm, P < 0.001) and volume (343.4 mm, P < 0.001), as well as increase in lumen area (54.4 mm, P < 0.001) and volume (1038 mm, P < 0.001). LDL-c lowering was significantly associated with aortic wall area and volume reduction in both groups. CONCLUSION: High-dose statin leads to greater LDL-c reduction, aortic vessel wall reduction and lumen increase than low-dose statin therapy in patients with at least moderate-documented atherosclerosis.
AB - Objective: We sought to compare the effects of high-dose with low-dose simvastatin therapy on aortic plaque morphology using transoesophageal magnetic resonance imaging (TEMRI). METHODS: Thirty-one patients with established moderate-to-severe atherosclerosis were recruited and randomized to 80 versus 20 mg/day simvastatin therapy. Aortic vessel wall and lumen volumes and areas were measured by TEMRI at baseline and 12 months. RESULTS: Significant differences were observed between the low-dose and high-dose statin therapy in reduction of low-density lipoprotein cholesterol (LDL-c) (10 mg/dl, P = 0.001), total cholesterol (16.2 mg/dl, P < 0.001), vessel wall area (19.0 mm, P < 0.001) and volume (343.4 mm, P < 0.001), as well as increase in lumen area (54.4 mm, P < 0.001) and volume (1038 mm, P < 0.001). LDL-c lowering was significantly associated with aortic wall area and volume reduction in both groups. CONCLUSION: High-dose statin leads to greater LDL-c reduction, aortic vessel wall reduction and lumen increase than low-dose statin therapy in patients with at least moderate-documented atherosclerosis.
KW - Adverse cardiovascular events
KW - Aorta
KW - Atherosclerosis
KW - Magnetic resonance imaging
KW - Statins
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UR - http://www.scopus.com/inward/citedby.url?scp=55249106998&partnerID=8YFLogxK
U2 - 10.2459/JCM.0b013e3282f447c3
DO - 10.2459/JCM.0b013e3282f447c3
M3 - Article
C2 - 18545070
AN - SCOPUS:55249106998
SN - 1558-2027
VL - 9
SP - 700
EP - 706
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
IS - 7
ER -