Aortic dilatation in children with mild to moderate chronic kidney disease

Peace C. Madueme, Derek K. Ng, Luke Guju, Lauren Longshore, Vicky Moore, Lynn Jefferies, Bradley A. Warady, Susan Furth, Mark Mitsnefes

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Children with mild to moderate chronic kidney disease are at an increased risk for cardiovascular sequelae, the leading cause of death in children with end-stage renal disease. We aimed to establish the prevalence of aortic dilatation, a newly recognized cardiovascular sequelae of renal disease, within a cohort of pediatric patients with mild to moderate kidney disease. Methods: A total of 501 children enrolled in the Chronic Kidney Disease in Children study contributed imaging data between April 2011 and February 2015. Aortic dilatation was defined as a dimension exceeding a z-score of 2 at any of three locations: aortic root, sinotubular junction, or the ascending aorta. Results: At baseline echocardiographic evaluation, 30 (6%) children were identified to have aortic dilatation in at least one of the three locations. Multivariate analysis demonstrated an increased odds ratio for the presence of aortic dilatation associated with the following variables: high diastolic blood pressure z-scores, low weight z-score, and low body mass index z-score. Presense of protein energy wasting (modified definition, OR 2.41, 95%CI 1.23, 4.70) was the strongest independent predictor of aortic dilatation. Conclusion: In conclusion, aortic dilatation does occur early in the course of chronic kidney disease and associates with markers of poor nutrition. Future studies should continue to evaluate these risk factors longitudinally as the kidney disease progresses.

Original languageEnglish (US)
Pages (from-to)1023-1031
Number of pages9
JournalPediatric Nephrology
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • Aortic dilatation
  • Cardiovascular disease
  • Chronic kidney disease
  • Malnutrition
  • Protein energy wasting

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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