Aortic diameter and pressure-flow sequence identify mechanism of blood flow during external chest compression in dogs

Alan D. Guerci, Henry R. Halperin, Rafael Beyar, Charles Beattie, Joshua E. Tsitlik, Edward C. Wurmb, Nisha C. Chandra, Myron L. Weisfeldt

Research output: Contribution to journalArticlepeer-review

Abstract

Aortic flow and pressure relations and aortic diameter were examined during sinus rhythm, internal cardiac massage, vest cardiopulmonary resuscitation, conventional manual cardiopulmonary resuscitation and high impulse manual cardiopulmonary resuscitation in 14 anesthetized large dogs. During sinus rhythm and during internal cardiac massage, ascending aortic flow and pressure increased simultaneously and the rise in ascending aorta pressure preceded the rise in descending aortic pressure by (mean ± SEM) 28 ± 4 and 30 ± 1 ms, respectively. In contrast, during vest, conventional and high impulse cardiopulmonary resuscitation, ascending aortic flow lagged behind the initial rise in aortic pressure by 40 ± 4 to 46 ± 4 ms and ascending and descending aortic pressure increased simultaneously (p < 0.001 for each external compression mode versus sinus rhythm and internal massage). The ratio of pulse pressure to stroke volume increased by an order of magnitude during all modes of external chest compression (p < 0.001 versus sinus rhythm and internal massage) and aortic diameter decreased during vest and high impulse cardiopulmonary resuscitation (p < 0.05 versus sinus rhythm and internal massage). The hemodynamics of external chest compression depart from the normal physiologic sequence of stroke volume-induced increase in aortic pressure and diameter. The rise in aortic pressure precedes flow into the aorta, stroke volume does not fully account for pulse pressure, and aortic diameter decreases during chest compression. These data support the hypothesis that blood flow is due to fluctuations in intrathoracic pressure for high impulse as well as vest and conventional cardiopulmonary resuscitation.

Original languageEnglish (US)
Pages (from-to)790-798
Number of pages9
JournalJournal of the American College of Cardiology
Volume14
Issue number3
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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