Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events: The MESA (Multi-Ethnic Study of Atherosclerosis)

Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R. Chugh, Alban Redheuil, Chia Ying Liu, Colin O. Wu, W. Gregory Hundley, David A. Bluemke, Eliseo Guallar, Joao A.C. Lima

Research output: Contribution to journalArticle

Abstract

The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in relation to arch PWV adjusted for age, sex, race, and CVD risk factors. The median value of arch PWV was 7.4 m/s (interquartile range, 5.6-10.2). There was significant interaction between arch PWV and age for outcomes, so analysis was stratified by age categories (45-54 and >54 years). There were 456 CVD events during the 10-year follow-up. Forty-five to 54-year-old participants had significant association of arch PWV with incident CVD independent of CVD risk factors (hazard ratio, 1.44; 95% confidence interval, 1.07-1.95; P=0.018; per 1-SD increase for logarithmically transformed PWV), whereas >54-year group did not (P=0.93). Aortic arch PWV assessed by magnetic resonance imaging is a significant predictor of CVD events among middle-aged (45-54 years old) individuals, whereas arch PWV is not associated with CVD among an elderly in a large multiethnic population.

LanguageEnglish (US)
Pages524-530
Number of pages7
JournalHypertension
Volume70
Issue number3
DOIs
StatePublished - Sep 1 2017

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Pulse Wave Analysis
Thoracic Aorta
Atherosclerosis
Cardiovascular Diseases
Magnetic Resonance Imaging
Transient Ischemic Attack
Coronary Disease
Heart Failure
Stroke
Confidence Intervals

Keywords

  • cardiovascular diseases
  • coronary artery disease
  • heart failure
  • pulse wave analysis
  • vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events : The MESA (Multi-Ethnic Study of Atherosclerosis). / Ohyama, Yoshiaki; Ambale-Venkatesh, Bharath; Noda, Chikara; Kim, Jang Young; Tanami, Yutaka; Teixido-Tura, Gisela; Chugh, Atul R.; Redheuil, Alban; Liu, Chia Ying; Wu, Colin O.; Hundley, W. Gregory; Bluemke, David A.; Guallar, Eliseo; Lima, Joao A.C.

In: Hypertension, Vol. 70, No. 3, 01.09.2017, p. 524-530.

Research output: Contribution to journalArticle

Ohyama, Yoshiaki ; Ambale-Venkatesh, Bharath ; Noda, Chikara ; Kim, Jang Young ; Tanami, Yutaka ; Teixido-Tura, Gisela ; Chugh, Atul R. ; Redheuil, Alban ; Liu, Chia Ying ; Wu, Colin O. ; Hundley, W. Gregory ; Bluemke, David A. ; Guallar, Eliseo ; Lima, Joao A.C./ Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events : The MESA (Multi-Ethnic Study of Atherosclerosis). In: Hypertension. 2017 ; Vol. 70, No. 3. pp. 524-530
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