TY - JOUR
T1 - Anxiolytic effect of noscapine in mice
AU - Khodarahmi, Parvin
AU - Rostami, Parvin
AU - Rashidi, Armin
AU - Khodarahmi, Iman
PY - 2006/9/20
Y1 - 2006/9/20
N2 - The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg. The parameter measured in dark-light model was the time spent in lit compartment. Intraperitoneal administration of noscapine (0.1-0.5 mg/kg) did not produce a significant effect on the time spent in the light, whereas higher doses (0.8, 1, 1.5 and 2 mg/kg) increased it significantly, implying an anxiolytic effect.
AB - The anxiety-related effects of noscapine were investigated using male Balb-c mice. Since noscapine-induced locomotion may alter the animals' activity level in the dark-light model, the anxiety-related effects of noscapine were studied at doses with no effect on locomotion (0.1, 0.2, 0.3, 0.4, 0.5, 0.8, 1, 1.5 and 2 mg/kg. The parameter measured in dark-light model was the time spent in lit compartment. Intraperitoneal administration of noscapine (0.1-0.5 mg/kg) did not produce a significant effect on the time spent in the light, whereas higher doses (0.8, 1, 1.5 and 2 mg/kg) increased it significantly, implying an anxiolytic effect.
KW - Anxiety
KW - Dark-light model
KW - Mice
KW - Noscapine
UR - http://www.scopus.com/inward/record.url?scp=33748661277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748661277&partnerID=8YFLogxK
M3 - Article
C2 - 16963805
AN - SCOPUS:33748661277
VL - 58
SP - 568
EP - 570
JO - Pharmacological Reports
JF - Pharmacological Reports
SN - 1734-1140
IS - 4
ER -