TY - JOUR
T1 - Anxiety in Parkinson’s Disease
T2 - A Systematic Review of Neuroimaging Studies
AU - Perepezko, Kate
AU - Naaz, Farah
AU - Wagandt, Carrie
AU - Dissanayaka, Nadeeka N.
AU - Mari, Zoltan
AU - Nanavati, Julie
AU - Bakker, Arnold
AU - Pontone, Gregory M.
N1 - Publisher Copyright:
© 2021, American Psychiatric Association. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective: The mechanisms and neuronal networks associated with anxiety in Parkinson’s disease (PD) are incom-pletely understood. One of the best tools for investigating both component function and neuronal networks associated with psychiatric symptoms is functional MRI (fMRI). Unlike structural scans, functional scans, whether task-based or resting-state, are more likely to be clinically rele-vant and sensitive to changes related to treatment. The investigators provide a comprehensive review of and present results for imaging studies of anxiety in PD. Methods: A systematic review of the literature on fMRI and anxiety in PD was conducted, and the quality of all included studies was simultaneously assessed. Eighteen studies were included: 15 studies assessed anxiety directly, and three evaluated emotional processing. Imaging methodology and behavioral assessments varied across studies, prevent-ing direct comparison of results in most cases. Results: There was a convergence in findings across meth-ods, implicating involvement of the amygdala, caudate, and putamen in association with anxiety in PD. For both task-based activation and resting-state connectivity, dopamine medication status was associated with differences in activation and behavioral function. Conclusions: Although there is little consensus in the current fMRI literature studying anxiety in PD, these results suggest an overlap between structures classically involved in the brain’s fear circuit (particularly the amygdala) and the alterations in the nigro-striatal system (e.g., the caudate and putamen and on-off dopamine findings) related to PD and its dopaminergic treatments.
AB - Objective: The mechanisms and neuronal networks associated with anxiety in Parkinson’s disease (PD) are incom-pletely understood. One of the best tools for investigating both component function and neuronal networks associated with psychiatric symptoms is functional MRI (fMRI). Unlike structural scans, functional scans, whether task-based or resting-state, are more likely to be clinically rele-vant and sensitive to changes related to treatment. The investigators provide a comprehensive review of and present results for imaging studies of anxiety in PD. Methods: A systematic review of the literature on fMRI and anxiety in PD was conducted, and the quality of all included studies was simultaneously assessed. Eighteen studies were included: 15 studies assessed anxiety directly, and three evaluated emotional processing. Imaging methodology and behavioral assessments varied across studies, prevent-ing direct comparison of results in most cases. Results: There was a convergence in findings across meth-ods, implicating involvement of the amygdala, caudate, and putamen in association with anxiety in PD. For both task-based activation and resting-state connectivity, dopamine medication status was associated with differences in activation and behavioral function. Conclusions: Although there is little consensus in the current fMRI literature studying anxiety in PD, these results suggest an overlap between structures classically involved in the brain’s fear circuit (particularly the amygdala) and the alterations in the nigro-striatal system (e.g., the caudate and putamen and on-off dopamine findings) related to PD and its dopaminergic treatments.
UR - http://www.scopus.com/inward/record.url?scp=85121157263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121157263&partnerID=8YFLogxK
U2 - 10.1176/appi.neuropsych.20110272
DO - 10.1176/appi.neuropsych.20110272
M3 - Article
C2 - 34280319
AN - SCOPUS:85121157263
SN - 0895-0172
VL - 33
SP - 280
EP - 294
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 4
ER -