Anxiety and self-perceived health status in Parkinson's disease

Gregory M Pontone, James R. Williams, Karen E. Anderson, Gary Chase, Susanne R. Goldstein, Stephen Grill, Elaina S. Hirsch, Susan Weinberger Lehmann, John T. Little, Russell Louis Margolis, Peter V Rabins, Howard D. Weiss, Laura Marsh

Research output: Contribution to journalArticle

Abstract

Both anxiety and depression are associated with lower self-perceived health status (HS) in persons with Parkinson's disease (PD). Given the high co-morbidity with depression and other non-motor symptoms, it is unclear whether anxiety disorders, in general, versus specific anxiety subtypes have an independent effect on HS in PD. To examine this question, comprehensive assessments of motor and non-motor symptoms from 249 subjects with idiopathic PD followed in three community-based movement disorders neurology practices were analyzed. HS was measured using the 8-item PD Questionnaire (PDQ-8). Psychiatric diagnoses were established by consensus using a panel of six psychiatrists with expertise in geriatric psychiatry and movement disorders. Stepwise multiple regression analyses were used, with the PDQ-8 score as the dependent variable, to identify independent predictors of HS among motor, psychiatric, and other non-motor variables. Among the anxiety disorders, only anxiety associated with motor fluctuations was an independent predictor of HS after accounting for co-morbid depression and other clinical features. In addition, depressive disorders were also an independent predictor of lower HS. Prevention or treatment of state-dependent anxiety may improve HS in persons with PD.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalParkinsonism and Related Disorders
Volume17
Issue number4
DOIs
StatePublished - May 2011

Fingerprint

Health Status
Parkinson Disease
Anxiety
Movement Disorders
Depression
Anxiety Disorders
Psychiatry
Geriatric Psychiatry
Depressive Disorder
Neurology
Mental Disorders
Consensus
Regression Analysis
Morbidity

Keywords

  • Anxiety
  • Fluctuations
  • Non-motor symptoms
  • Parkinson's disease
  • Psychiatric disorders
  • Quality of life

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Pontone, G. M., Williams, J. R., Anderson, K. E., Chase, G., Goldstein, S. R., Grill, S., ... Marsh, L. (2011). Anxiety and self-perceived health status in Parkinson's disease. Parkinsonism and Related Disorders, 17(4), 249-254. https://doi.org/10.1016/j.parkreldis.2011.01.005

Anxiety and self-perceived health status in Parkinson's disease. / Pontone, Gregory M; Williams, James R.; Anderson, Karen E.; Chase, Gary; Goldstein, Susanne R.; Grill, Stephen; Hirsch, Elaina S.; Lehmann, Susan Weinberger; Little, John T.; Margolis, Russell Louis; Rabins, Peter V; Weiss, Howard D.; Marsh, Laura.

In: Parkinsonism and Related Disorders, Vol. 17, No. 4, 05.2011, p. 249-254.

Research output: Contribution to journalArticle

Pontone, GM, Williams, JR, Anderson, KE, Chase, G, Goldstein, SR, Grill, S, Hirsch, ES, Lehmann, SW, Little, JT, Margolis, RL, Rabins, PV, Weiss, HD & Marsh, L 2011, 'Anxiety and self-perceived health status in Parkinson's disease', Parkinsonism and Related Disorders, vol. 17, no. 4, pp. 249-254. https://doi.org/10.1016/j.parkreldis.2011.01.005
Pontone, Gregory M ; Williams, James R. ; Anderson, Karen E. ; Chase, Gary ; Goldstein, Susanne R. ; Grill, Stephen ; Hirsch, Elaina S. ; Lehmann, Susan Weinberger ; Little, John T. ; Margolis, Russell Louis ; Rabins, Peter V ; Weiss, Howard D. ; Marsh, Laura. / Anxiety and self-perceived health status in Parkinson's disease. In: Parkinsonism and Related Disorders. 2011 ; Vol. 17, No. 4. pp. 249-254.
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