Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study

A. F G Leentjens, K. Dujardin, L. Marsh, P. Martinez-Martin, I. H. Richard, S. E. Starkstein

Research output: Contribution to journalArticle

Abstract

Background: Some studies have suggested a relationship between anxiety and motor fluctuations in patients with Parkinson's disease (PD). Aim: To describe the nature of the relationship between anxiety symptoms and motor fluctuations and to describe the anxiety symptoms encountered during 'off', 'on' and 'on with dyskinesia' phases. Design and methods: In this cross-sectional study, 250 patients with idiopathic PD, of whom 118 had motor fluctuations, underwent a standardized clinical assessment including the Unified Parkinson's Disease Rating Scale (UPDRS), the DSM IV criteria for major depression and anxiety disorders, the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HARS). In addition, patients with motor fluctuations were administered a questionnaire to assess the presence of anxiety symptoms and their relation to motor states. Results: Patients with motor fluctuations suffer from generalized anxiety disorder more often than patients without motor fluctuations. When patients with motor fluctuations have anxiety symptoms, the majority report that these have no temporal relationship with specific motor states. When there was a relationship, symptoms were almost always related to 'off' periods. However, a minority of patients experience anxiety symptoms during 'on' or "on with dyskinesia" periods exclusively. Conclusion: Our findings suggest that the relationship between anxiety and motor fluctuations is more complex than can be explained solely by 'wearing off' phenomena of levodopa. Further studies investigating the temporal dynamics of anxiety and motor fluctuations are needed.

Original languageEnglish (US)
Pages (from-to)1084-1088
Number of pages5
JournalParkinsonism and Related Disorders
Volume18
Issue number10
DOIs
StatePublished - Dec 2012

Fingerprint

Observational Studies
Parkinson Disease
Anxiety
Cross-Sectional Studies
Dyskinesias
Anxiety Disorders
Depression
Levodopa
Diagnostic and Statistical Manual of Mental Disorders

Keywords

  • Anxiety
  • Motor fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Leentjens, A. F. G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I. H., & Starkstein, S. E. (2012). Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study. Parkinsonism and Related Disorders, 18(10), 1084-1088. https://doi.org/10.1016/j.parkreldis.2012.06.007

Anxiety and motor fluctuations in Parkinson's disease : A cross-sectional observational study. / Leentjens, A. F G; Dujardin, K.; Marsh, L.; Martinez-Martin, P.; Richard, I. H.; Starkstein, S. E.

In: Parkinsonism and Related Disorders, Vol. 18, No. 10, 12.2012, p. 1084-1088.

Research output: Contribution to journalArticle

Leentjens, AFG, Dujardin, K, Marsh, L, Martinez-Martin, P, Richard, IH & Starkstein, SE 2012, 'Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study', Parkinsonism and Related Disorders, vol. 18, no. 10, pp. 1084-1088. https://doi.org/10.1016/j.parkreldis.2012.06.007
Leentjens, A. F G ; Dujardin, K. ; Marsh, L. ; Martinez-Martin, P. ; Richard, I. H. ; Starkstein, S. E. / Anxiety and motor fluctuations in Parkinson's disease : A cross-sectional observational study. In: Parkinsonism and Related Disorders. 2012 ; Vol. 18, No. 10. pp. 1084-1088.
@article{1213ad2cc4e445418a5e88c788d75ab8,
title = "Anxiety and motor fluctuations in Parkinson's disease: A cross-sectional observational study",
abstract = "Background: Some studies have suggested a relationship between anxiety and motor fluctuations in patients with Parkinson's disease (PD). Aim: To describe the nature of the relationship between anxiety symptoms and motor fluctuations and to describe the anxiety symptoms encountered during 'off', 'on' and 'on with dyskinesia' phases. Design and methods: In this cross-sectional study, 250 patients with idiopathic PD, of whom 118 had motor fluctuations, underwent a standardized clinical assessment including the Unified Parkinson's Disease Rating Scale (UPDRS), the DSM IV criteria for major depression and anxiety disorders, the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HARS). In addition, patients with motor fluctuations were administered a questionnaire to assess the presence of anxiety symptoms and their relation to motor states. Results: Patients with motor fluctuations suffer from generalized anxiety disorder more often than patients without motor fluctuations. When patients with motor fluctuations have anxiety symptoms, the majority report that these have no temporal relationship with specific motor states. When there was a relationship, symptoms were almost always related to 'off' periods. However, a minority of patients experience anxiety symptoms during 'on' or {"}on with dyskinesia{"} periods exclusively. Conclusion: Our findings suggest that the relationship between anxiety and motor fluctuations is more complex than can be explained solely by 'wearing off' phenomena of levodopa. Further studies investigating the temporal dynamics of anxiety and motor fluctuations are needed.",
keywords = "Anxiety, Motor fluctuations, Parkinson's disease",
author = "Leentjens, {A. F G} and K. Dujardin and L. Marsh and P. Martinez-Martin and Richard, {I. H.} and Starkstein, {S. E.}",
year = "2012",
month = "12",
doi = "10.1016/j.parkreldis.2012.06.007",
language = "English (US)",
volume = "18",
pages = "1084--1088",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - Anxiety and motor fluctuations in Parkinson's disease

T2 - A cross-sectional observational study

AU - Leentjens, A. F G

AU - Dujardin, K.

AU - Marsh, L.

AU - Martinez-Martin, P.

AU - Richard, I. H.

AU - Starkstein, S. E.

PY - 2012/12

Y1 - 2012/12

N2 - Background: Some studies have suggested a relationship between anxiety and motor fluctuations in patients with Parkinson's disease (PD). Aim: To describe the nature of the relationship between anxiety symptoms and motor fluctuations and to describe the anxiety symptoms encountered during 'off', 'on' and 'on with dyskinesia' phases. Design and methods: In this cross-sectional study, 250 patients with idiopathic PD, of whom 118 had motor fluctuations, underwent a standardized clinical assessment including the Unified Parkinson's Disease Rating Scale (UPDRS), the DSM IV criteria for major depression and anxiety disorders, the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HARS). In addition, patients with motor fluctuations were administered a questionnaire to assess the presence of anxiety symptoms and their relation to motor states. Results: Patients with motor fluctuations suffer from generalized anxiety disorder more often than patients without motor fluctuations. When patients with motor fluctuations have anxiety symptoms, the majority report that these have no temporal relationship with specific motor states. When there was a relationship, symptoms were almost always related to 'off' periods. However, a minority of patients experience anxiety symptoms during 'on' or "on with dyskinesia" periods exclusively. Conclusion: Our findings suggest that the relationship between anxiety and motor fluctuations is more complex than can be explained solely by 'wearing off' phenomena of levodopa. Further studies investigating the temporal dynamics of anxiety and motor fluctuations are needed.

AB - Background: Some studies have suggested a relationship between anxiety and motor fluctuations in patients with Parkinson's disease (PD). Aim: To describe the nature of the relationship between anxiety symptoms and motor fluctuations and to describe the anxiety symptoms encountered during 'off', 'on' and 'on with dyskinesia' phases. Design and methods: In this cross-sectional study, 250 patients with idiopathic PD, of whom 118 had motor fluctuations, underwent a standardized clinical assessment including the Unified Parkinson's Disease Rating Scale (UPDRS), the DSM IV criteria for major depression and anxiety disorders, the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating Scale (HARS). In addition, patients with motor fluctuations were administered a questionnaire to assess the presence of anxiety symptoms and their relation to motor states. Results: Patients with motor fluctuations suffer from generalized anxiety disorder more often than patients without motor fluctuations. When patients with motor fluctuations have anxiety symptoms, the majority report that these have no temporal relationship with specific motor states. When there was a relationship, symptoms were almost always related to 'off' periods. However, a minority of patients experience anxiety symptoms during 'on' or "on with dyskinesia" periods exclusively. Conclusion: Our findings suggest that the relationship between anxiety and motor fluctuations is more complex than can be explained solely by 'wearing off' phenomena of levodopa. Further studies investigating the temporal dynamics of anxiety and motor fluctuations are needed.

KW - Anxiety

KW - Motor fluctuations

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=84870547771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870547771&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2012.06.007

DO - 10.1016/j.parkreldis.2012.06.007

M3 - Article

C2 - 22771284

AN - SCOPUS:84870547771

VL - 18

SP - 1084

EP - 1088

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 10

ER -