ANTIVIRAL ACTIVITY OF MEROCYANINE 540

Fritz Sieber, Jill M. O'Brien, Gregory J. Krueger, Sheri L. Schober, William H. Burns, Saul J. Sharkis, Lyle L. Sensenbrenner

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract Simultaneous exposure to the lipophilic dye merocyanine 540 (MC 540) and white light inactivates several enveloped viruses. The same treatment appears to have little or no effect on pluripotent hematopoietic stem cells, mature red cells, and mature leukocytes. At least some components of the clotting system are spared, too. The molecular basis of the virucidal effect of MC 540 and light is not yet completely understood. Based on what is known about the interactions of MC 540 with cells and artificial membranes, it seems likely that MC 540 binds to and damages the viral envelope. MC 540‐mediated photosensitization may have implications for the sterilization of bone marrow and blood products, the preparation of vaccines, and selected areas of antiviral therapy.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalPhotochemistry and Photobiology
Volume46
Issue number5
DOIs
StatePublished - Nov 1987

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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