Antiviral activity of colostrum and serum immunoglobulins a and g

E. L. Palmer, G. W. Gary, R. Black, M. L. Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Enteric virus‐specific IgA and IgG present in paired human sera and colostrums were measured by the enzyme‐linked immunosorbent assay (ELISA). Virus‐specific IgA was present in all colostrums, but virus‐specific IgG could not be detected. The reverse was true when sera were assayed. Most of these colostrums also neutralized either polio virus or reovirus, as did IgA, which was separated from a pool of colostrums by exclusion chromatography. No correlation could be made between levels of neutralizing and ELISA antibody titers in colostrums.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalJournal of Medical Virology
Volume5
Issue number2
DOIs
StatePublished - 1980

Keywords

  • ELISA
  • colostrum
  • neutralization
  • secretory immunoglobulin A

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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