TY - JOUR
T1 - Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo
AU - Li, Xiaohong
AU - Li, Xiaodong
AU - Huang, Jianyong
AU - Wei, Lixin
AU - Chen, Lieping
AU - Wu, Mengchao
AU - Guo, Yajun
PY - 2002
Y1 - 2002
N2 - OBJECTIVE: To study the effects of 4-1BBL on antitumor immunity induced in vivo by murine 4-1BBL gene transfected Hepa1-6. METHODS: Retrovirus vector was used to transfer the 4-1BBL gene into syngeneic murine heptocellular carcinoma cell line Hepa1-6. The products were termed as Hepa1-6/4-1BBL, and then the TCV4-1BBL was obtained by treating them with mitomycin (MMC). Three models (immunological model, early model, and later model) were established to study the antitumor effects of TCV4-1BBL. RESULTS: (1)In immunological models, the syngeneic mice were completely protected by inoculation with TCV4-1BBL, survived free from tumor for a long period (over 100 days). (2)In early models (7 days after inoculation), Hepa1-6 tumor cells showed strong immunogenicity effects and (3) In later models (14 days after inoculation), they had obvious antitumor effects and most of the tumors were disappeared. CONCLUSIONS: The antitumor effect against syngeneic murine hepatocellular carcinoma in vivo is obviously enhanced by treating them with TCV4-1BBL
AB - OBJECTIVE: To study the effects of 4-1BBL on antitumor immunity induced in vivo by murine 4-1BBL gene transfected Hepa1-6. METHODS: Retrovirus vector was used to transfer the 4-1BBL gene into syngeneic murine heptocellular carcinoma cell line Hepa1-6. The products were termed as Hepa1-6/4-1BBL, and then the TCV4-1BBL was obtained by treating them with mitomycin (MMC). Three models (immunological model, early model, and later model) were established to study the antitumor effects of TCV4-1BBL. RESULTS: (1)In immunological models, the syngeneic mice were completely protected by inoculation with TCV4-1BBL, survived free from tumor for a long period (over 100 days). (2)In early models (7 days after inoculation), Hepa1-6 tumor cells showed strong immunogenicity effects and (3) In later models (14 days after inoculation), they had obvious antitumor effects and most of the tumors were disappeared. CONCLUSIONS: The antitumor effect against syngeneic murine hepatocellular carcinoma in vivo is obviously enhanced by treating them with TCV4-1BBL
UR - http://www.scopus.com/inward/record.url?scp=1842870803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842870803&partnerID=8YFLogxK
M3 - Article
C2 - 12502438
AN - SCOPUS:1842870803
SN - 1007-3418
VL - 10
SP - 409
EP - 412
JO - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
JF - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
IS - 6
ER -