Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

Hidayat Hussain; Nazia Bibi; Ahmed Al-Harrasi; Salman Siddiqi; Shahana U. Kazmi; Ying Zhang; Amin Badshah

doi:10.1016/j.cclet.2012.03.011

Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

Hidayat Hussain, Nazia Bibi, Ahmed Al-Harrasi, Salman Siddiqi, Shahana U. Kazmi, Ying Zhang, Amin Badshah

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by ¹H- ¹³C- ¹¹⁹Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 μg/mL.

Original language	English (US)
Pages (from-to)	731-735
Number of pages	5
Journal	Chinese Chemical Letters
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.cclet.2012.03.011
State	Published - Jun 2012
Externally published	Yes

Keywords

Antituberculosis activity
Cytotoxicity
MICs
Triorganotin(IV) complexes

ASJC Scopus subject areas

General Chemistry

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10.1016/j.cclet.2012.03.011

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title = "Antituberculosis and cytotoxic activities of triorganotin(IV) complexes",

abstract = "Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by 1H- 13C- 119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 μg/mL.",

keywords = "Antituberculosis activity, Cytotoxicity, MICs, Triorganotin(IV) complexes",

author = "Hidayat Hussain and Nazia Bibi and Ahmed Al-Harrasi and Salman Siddiqi and Kazmi, {Shahana U.} and Ying Zhang and Amin Badshah",

note = "Funding Information: This study was partially supported by IRSIP-HEC fellowship to NB. SS is highly acknowledged for facilitating this study by providing lab supplies. ",

year = "2012",

month = jun,

doi = "10.1016/j.cclet.2012.03.011",

language = "English (US)",

volume = "23",

pages = "731--735",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier",

number = "6",

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TY - JOUR

T1 - Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

AU - Hussain, Hidayat

AU - Bibi, Nazia

AU - Al-Harrasi, Ahmed

AU - Siddiqi, Salman

AU - Kazmi, Shahana U.

AU - Zhang, Ying

AU - Badshah, Amin

N1 - Funding Information: This study was partially supported by IRSIP-HEC fellowship to NB. SS is highly acknowledged for facilitating this study by providing lab supplies.

PY - 2012/6

Y1 - 2012/6

N2 - Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by 1H- 13C- 119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 μg/mL.

AB - Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by 1H- 13C- 119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 μg/mL.

KW - Antituberculosis activity

KW - Cytotoxicity

KW - MICs

KW - Triorganotin(IV) complexes

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U2 - 10.1016/j.cclet.2012.03.011

DO - 10.1016/j.cclet.2012.03.011

M3 - Article

AN - SCOPUS:84861341263

SN - 1001-8417

VL - 23

SP - 731

EP - 735

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 6

ER -

Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

Abstract

Keywords

ASJC Scopus subject areas

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