Antituberculosis and cytotoxic activities of triorganotin(IV) complexes

Hidayat Hussain, Nazia Bibi, Ahmed Al-Harrasi, Salman Siddiqi, Shahana U. Kazmi, Ying Zhang, Amin Badshah

Research output: Contribution to journalArticlepeer-review

Abstract

Five triorganotin(IV) (1-5) complexes of cinnamic acid, (Z)-2-acetamido-3-phenylacrylic acid, 3-methylbut-2-enoic acid, and 2,2-diphenylacetic acid have been synthesized and characterized by 1H- 13C- 119Sn NMR, UV, and IR. The spectroscopic investigation demonstrated that the carboxylate group acts as a monodentate ligand in triorganotin(IV) compounds. Five triorganotin(IV) complexes were screened against the log phase culture of Mycobacterium tuberculosis H37Rv by colorimetric method using XTT dye as growth indicator. The MICs were found to be 0.08 and 1.25 μg/mL.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalChinese Chemical Letters
Volume23
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Antituberculosis activity
  • Cytotoxicity
  • MICs
  • Triorganotin(IV) complexes

ASJC Scopus subject areas

  • Chemistry(all)

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