Antitrypanosomal activity of fluoroquinolones

Elizabeth Nenortas, Christian Burri, Theresa A. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Six fluoroquinolones presently in clinical use and four investigational tetracyclic fluoroquinolones were tested for in vitro activity against bloodstream-form Trypanosoma brucei brucei. All compounds had measurable activity, but the tetracyclic analogs were most potent, with 50% effective concentrations in the low micromolar range. In general, trypanosomes were more susceptible than L1210 leukemia cells. Consistent with the notion that they target type H topoisomerase in trypanosomes, the fluoroquinolones promote the formation of protein-DNA covalent complexes.

Original languageEnglish (US)
Pages (from-to)2066-2068
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume43
Issue number8
DOIs
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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