Antitrypanosomal activities of tryptanthrins

John Scovill, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, Theresa A Shapiro

Research output: Contribution to journalArticle

Abstract

New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.

Original languageEnglish (US)
Pages (from-to)882-883
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number3
DOIs
StatePublished - 2002

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Trypanosoma brucei brucei
African Trypanosomiasis
Antifungal Agents
Electrons
Pharmaceutical Preparations
tryptanthrine
In Vitro Techniques
indolo(2,1-b)quinazoline

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Antitrypanosomal activities of tryptanthrins. / Scovill, John; Blank, Elizabeth; Konnick, Michael; Nenortas, Elizabeth; Shapiro, Theresa A.

In: Antimicrobial Agents and Chemotherapy, Vol. 46, No. 3, 2002, p. 882-883.

Research output: Contribution to journalArticle

Scovill, John ; Blank, Elizabeth ; Konnick, Michael ; Nenortas, Elizabeth ; Shapiro, Theresa A. / Antitrypanosomal activities of tryptanthrins. In: Antimicrobial Agents and Chemotherapy. 2002 ; Vol. 46, No. 3. pp. 882-883.
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