TY - JOUR
T1 - Antitrypanosomal activities of tryptanthrins
AU - Scovill, John
AU - Blank, Elizabeth
AU - Konnick, Michael
AU - Nenortas, Elizabeth
AU - Shapiro, Theresa
PY - 2002
Y1 - 2002
N2 - New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.
AB - New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.
UR - http://www.scopus.com/inward/record.url?scp=0036173160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036173160&partnerID=8YFLogxK
U2 - 10.1128/AAC.46.3.882-883.2002
DO - 10.1128/AAC.46.3.882-883.2002
M3 - Article
C2 - 11850279
AN - SCOPUS:0036173160
SN - 0066-4804
VL - 46
SP - 882
EP - 883
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 3
ER -