Antitrypanosomal activities of tryptanthrins

John Scovill, Elizabeth Blank, Michael Konnick, Elizabeth Nenortas, Theresa A Shapiro

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New drugs and molecular targets are needed against Trypanosoma brucei, the protozoan that causes African sleeping sickness. Tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), a traditional antifungal agent, and 11 analogs were tested against T. brucei in vitro. The greatest activity was conferred by electron-withdrawing groups in the 8 position of the tryptanthrin ring system; the most potent compound had a 50% effective concentration of 0.40 μM.

Original languageEnglish (US)
Pages (from-to)882-883
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Issue number3
Publication statusPublished - 2002


ASJC Scopus subject areas

  • Pharmacology (medical)

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