Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions

Elizabeth Nenortas, Tomasz Kulikowicz, Christian Burri, Theresa A. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.

Original languageEnglish (US)
Pages (from-to)3015-3017
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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