Abstract
Fluoroquinolones with pyrrolidinyl substitutions were tested against Trypanosoma brucei and mammalian cells. Bulky substituents at C-7 or a 1-2-bridging thiazolidine ring increased antitrypanosomal activity and selective toxicity. These compounds trap protein-DNA complexes and inhibit nucleic acid biosynthesis in trypanosomes, characteristics of topoisomerase II inhibition.
Original language | English (US) |
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Pages (from-to) | 3015-3017 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 47 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2003 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases