Antisocial personality and risks of cause-specific mortality: results from the Epidemiologic Catchment Area study with 27 years of follow-up

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Abstract

Purpose: Little is known about the effect of antisocial personality disorder (ASPD) on the risks of cause-specific mortality in the community. This study aimed to close this gap by evaluating if ASPD increases risks of cause-specific mortality in population-based residential and institutionalized samples with 27 years of follow-up. Methods: Data were collected in four metropolitan sites as part of the Epidemiologic Catchment Area (ECA) study during 1979–1983. Records were linked to the National Death Index through the end of 2007. Cox proportional hazards models adjusted for propensity weights and sample weights were fitted to estimate the effect of ASPD on the hazard of dying. Results: 420 respondents with ASPD (median survival age 71.0 years) and 15,367 without ASPD (median survival age 84.6 years) were included in this study. Those with ASPD were more likely to die from all causes (HR = 4.46; 95% CI = 2.44–8.16), suicide (HR = 2.81; 95% CI = 1.03–7.65), malignant neoplasms (HR = 4.09; 95% CI = 2.66–6.28), chronic lower respiratory disease (HR = 5.67; 95% CI = 2.92–11.0), and human immunodeficiency virus infection (HR = 8.07; 95% CI = 2.03–32.1), but not from accidents (HR = 0.58; 95% CI = 0.17–1.93) or heart disease (HR = 1.09; 95% CI = 0.43–2.76). Conclusions: Our findings demonstrate that antisocial personality disorder is a strong predictor of all-cause mortality, and cause-specific mortality. Early identification, treatment, and prevention of ASPD are important public mental health initiatives that could reduce premature mortality among this vulnerable population.

Original languageEnglish (US)
JournalSocial Psychiatry and Psychiatric Epidemiology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Antisocial Personality Disorder
personality disorder
personality
mortality
cause
Mortality
Weights and Measures
Premature Mortality
Survival
Vulnerable Populations
Virus Diseases
heart disease
dying
Proportional Hazards Models
Suicide
suicide
Accidents
Heart Diseases
Mental Health
accident

Keywords

  • Antisocial personality disorder
  • Epidemiologic catchment area study
  • HIV
  • Mortality
  • Personality disorders
  • Suicide

ASJC Scopus subject areas

  • Epidemiology
  • Health(social science)
  • Social Psychology
  • Psychiatry and Mental health

Cite this

@article{3529ed7ab07d4cf28e9ebde0cffd1a5f,
title = "Antisocial personality and risks of cause-specific mortality: results from the Epidemiologic Catchment Area study with 27 years of follow-up",
abstract = "Purpose: Little is known about the effect of antisocial personality disorder (ASPD) on the risks of cause-specific mortality in the community. This study aimed to close this gap by evaluating if ASPD increases risks of cause-specific mortality in population-based residential and institutionalized samples with 27 years of follow-up. Methods: Data were collected in four metropolitan sites as part of the Epidemiologic Catchment Area (ECA) study during 1979–1983. Records were linked to the National Death Index through the end of 2007. Cox proportional hazards models adjusted for propensity weights and sample weights were fitted to estimate the effect of ASPD on the hazard of dying. Results: 420 respondents with ASPD (median survival age 71.0 years) and 15,367 without ASPD (median survival age 84.6 years) were included in this study. Those with ASPD were more likely to die from all causes (HR = 4.46; 95{\%} CI = 2.44–8.16), suicide (HR = 2.81; 95{\%} CI = 1.03–7.65), malignant neoplasms (HR = 4.09; 95{\%} CI = 2.66–6.28), chronic lower respiratory disease (HR = 5.67; 95{\%} CI = 2.92–11.0), and human immunodeficiency virus infection (HR = 8.07; 95{\%} CI = 2.03–32.1), but not from accidents (HR = 0.58; 95{\%} CI = 0.17–1.93) or heart disease (HR = 1.09; 95{\%} CI = 0.43–2.76). Conclusions: Our findings demonstrate that antisocial personality disorder is a strong predictor of all-cause mortality, and cause-specific mortality. Early identification, treatment, and prevention of ASPD are important public mental health initiatives that could reduce premature mortality among this vulnerable population.",
keywords = "Antisocial personality disorder, Epidemiologic catchment area study, HIV, Mortality, Personality disorders, Suicide",
author = "Anna Krasnova and Eaton, {William W} and Jack Samuels",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s00127-018-1628-5",
language = "English (US)",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "D. Steinkopff-Verlag",

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TY - JOUR

T1 - Antisocial personality and risks of cause-specific mortality

T2 - results from the Epidemiologic Catchment Area study with 27 years of follow-up

AU - Krasnova, Anna

AU - Eaton, William W

AU - Samuels, Jack

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Little is known about the effect of antisocial personality disorder (ASPD) on the risks of cause-specific mortality in the community. This study aimed to close this gap by evaluating if ASPD increases risks of cause-specific mortality in population-based residential and institutionalized samples with 27 years of follow-up. Methods: Data were collected in four metropolitan sites as part of the Epidemiologic Catchment Area (ECA) study during 1979–1983. Records were linked to the National Death Index through the end of 2007. Cox proportional hazards models adjusted for propensity weights and sample weights were fitted to estimate the effect of ASPD on the hazard of dying. Results: 420 respondents with ASPD (median survival age 71.0 years) and 15,367 without ASPD (median survival age 84.6 years) were included in this study. Those with ASPD were more likely to die from all causes (HR = 4.46; 95% CI = 2.44–8.16), suicide (HR = 2.81; 95% CI = 1.03–7.65), malignant neoplasms (HR = 4.09; 95% CI = 2.66–6.28), chronic lower respiratory disease (HR = 5.67; 95% CI = 2.92–11.0), and human immunodeficiency virus infection (HR = 8.07; 95% CI = 2.03–32.1), but not from accidents (HR = 0.58; 95% CI = 0.17–1.93) or heart disease (HR = 1.09; 95% CI = 0.43–2.76). Conclusions: Our findings demonstrate that antisocial personality disorder is a strong predictor of all-cause mortality, and cause-specific mortality. Early identification, treatment, and prevention of ASPD are important public mental health initiatives that could reduce premature mortality among this vulnerable population.

AB - Purpose: Little is known about the effect of antisocial personality disorder (ASPD) on the risks of cause-specific mortality in the community. This study aimed to close this gap by evaluating if ASPD increases risks of cause-specific mortality in population-based residential and institutionalized samples with 27 years of follow-up. Methods: Data were collected in four metropolitan sites as part of the Epidemiologic Catchment Area (ECA) study during 1979–1983. Records were linked to the National Death Index through the end of 2007. Cox proportional hazards models adjusted for propensity weights and sample weights were fitted to estimate the effect of ASPD on the hazard of dying. Results: 420 respondents with ASPD (median survival age 71.0 years) and 15,367 without ASPD (median survival age 84.6 years) were included in this study. Those with ASPD were more likely to die from all causes (HR = 4.46; 95% CI = 2.44–8.16), suicide (HR = 2.81; 95% CI = 1.03–7.65), malignant neoplasms (HR = 4.09; 95% CI = 2.66–6.28), chronic lower respiratory disease (HR = 5.67; 95% CI = 2.92–11.0), and human immunodeficiency virus infection (HR = 8.07; 95% CI = 2.03–32.1), but not from accidents (HR = 0.58; 95% CI = 0.17–1.93) or heart disease (HR = 1.09; 95% CI = 0.43–2.76). Conclusions: Our findings demonstrate that antisocial personality disorder is a strong predictor of all-cause mortality, and cause-specific mortality. Early identification, treatment, and prevention of ASPD are important public mental health initiatives that could reduce premature mortality among this vulnerable population.

KW - Antisocial personality disorder

KW - Epidemiologic catchment area study

KW - HIV

KW - Mortality

KW - Personality disorders

KW - Suicide

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U2 - 10.1007/s00127-018-1628-5

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