Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila

Elizabeth H. Chen, Eric N. Olson

Research output: Contribution to journalArticle

Abstract

Somatic muscle formation in Drosophila requires fusion of muscle founder cells with fusion-competent myoblasts. In a genetic screen for genes that control muscle development, we identified antisocial (ants), a gene that encodes an ankyrin repeat-, TPR repeat-, and RING finger-containing protein, required for myoblast fusion. In ants mutant embryos, founder cells and fusion-competent myoblasts are properly specified and patterned, but they are unable to form myotubes. ANTS, which is expressed specifically in founder cells, interacts with the cytoplasmic domain of Dumbfounded, a founder cell transmembrane receptor, and with Myoblast city, a cytoskeletal protein, both of which are also required for myoblast fusion. These findings suggest that ANTS functions as an intracellular adaptor protein that relays signals from Dumbfounded to the cytoskeleton during myoblast fusion.

Original languageEnglish (US)
Pages (from-to)705-715
Number of pages11
JournalDevelopmental Cell
Volume1
Issue number5
DOIs
StatePublished - Nov 2001
Externally publishedYes

Fingerprint

Myoblasts
Drosophila
Fusion reactions
Muscle
Proteins
Ants
Cell Fusion
Genes
Ankyrin Repeat
Cytoskeletal Proteins
Muscle Development
Skeletal Muscle Fibers
Cytoskeleton
Muscle Cells
Embryonic Structures
Muscles

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila. / Chen, Elizabeth H.; Olson, Eric N.

In: Developmental Cell, Vol. 1, No. 5, 11.2001, p. 705-715.

Research output: Contribution to journalArticle

Chen, Elizabeth H. ; Olson, Eric N. / Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila. In: Developmental Cell. 2001 ; Vol. 1, No. 5. pp. 705-715.
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