Antisense oligonucleotides for therapeutic intervention

Stephen L. Eck, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

Advances have been made in defining the best target sequences for use in antisense oligonucleotide technology, and new chemical derivatives of oligonucleotides are being investigated. Although the potential use of antisense oligonucleotide agents in the treatment of neoplastic, viral and parasitic diseases continues to be explored, they are not yet suitable for administration to humans for reasons that are discussed.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume2
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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