Antischizophrenic drugs: Differential plasma protein binding and therapeutic activity

Kenneth A. Freedberg, Robert B. Innis, Ian Creese, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review


The percentage of free neuroleptic drug unbound to plasma protein is much higher for the respective metabolites of chlorpromazine and thioridazine, 7-hydroxychlorpromazine and mesoridazine, than for the parent drugs. The therapeutic activities of chlorpromazine and thioridazine may be mediated to a major extent by 7-hydroxychlorpromazine and mesoridazine respectively. Measuring free levels of the active metabolites of neuroleptics as well as the parent drugs may facilitate regulation of neuroleptic doses to secure optimal therapeutic responses.

Original languageEnglish (US)
Pages (from-to)2467-2473
Number of pages7
JournalLife Sciences
Issue number26
StatePublished - Jun 25 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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