Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

David R. Burt, I. A N Creese, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

Original languageEnglish (US)
Pages (from-to)326-328
Number of pages3
JournalScience
Volume196
Issue number4287
StatePublished - 1977

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Dopamine Receptors
Haloperidol
Fluphenazine
Corpus Striatum
Reserpine
Brain
Pharmaceutical Preparations
Antipsychotic Agents
Therapeutics
Tardive Dyskinesia

ASJC Scopus subject areas

  • General

Cite this

Antischizophrenic drugs : Chronic treatment elevates dopamine receptor binding in brain. / Burt, David R.; Creese, I. A N; Snyder, Solomon H.

In: Science, Vol. 196, No. 4287, 1977, p. 326-328.

Research output: Contribution to journalArticle

Burt, David R. ; Creese, I. A N ; Snyder, Solomon H. / Antischizophrenic drugs : Chronic treatment elevates dopamine receptor binding in brain. In: Science. 1977 ; Vol. 196, No. 4287. pp. 326-328.
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