Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

David R. Burt, I. A.N. Creese, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

Original languageEnglish (US)
Pages (from-to)326-328
Number of pages3
JournalScience
Volume196
Issue number4287
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • General

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