Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

David R. Burt; I. A.N. Creese; Solomon H. Snyder

doi:10.1126/science.847477

Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

David R. Burt, I. A.N. Creese, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

854 Scopus citations

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [³H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

Original language	English (US)
Pages (from-to)	326-328
Number of pages	3
Journal	Science
Volume	196
Issue number	4287
DOIs	https://doi.org/10.1126/science.847477
State	Published - 1977

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title = "Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain",

abstract = "Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.",

author = "Burt, {David R.} and Creese, {I. A.N.} and Snyder, {Solomon H.}",

year = "1977",

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AB - Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

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Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

Abstract

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