Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain

David R. Burt, I. A N Creese, Solomon H Snyder

Research output: Contribution to journal › Article

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

Original languageEnglish (US)
Pages (from-to)326-328
Number of pages3
JournalScience
Volume196
Issue number4287
StatePublished - 1977

Fingerprint

Dopamine Receptors
Haloperidol
Fluphenazine
Corpus Striatum
Reserpine
Brain
Pharmaceutical Preparations
Antipsychotic Agents
Therapeutics
Tardive Dyskinesia

ASJC Scopus subject areas

  • General

Cite this

Antischizophrenic drugs : Chronic treatment elevates dopamine receptor binding in brain. / Burt, David R.; Creese, I. A N; Snyder, Solomon H.

In: Science, Vol. 196, No. 4287, 1977, p. 326-328.

Research output: Contribution to journal › Article

Burt, DR, Creese, IAN & Snyder, SH 1977, 'Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain', Science, vol. 196, no. 4287, pp. 326-328.
Burt DR, Creese IAN, Snyder SH. Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain. Science. 1977;196(4287):326-328.
Burt, David R. ; Creese, I. A N ; Snyder, Solomon H. / Antischizophrenic drugs : Chronic treatment elevates dopamine receptor binding in brain. In: Science. 1977 ; Vol. 196, No. 4287. pp. 326-328.
@article{ee9c6bebb5ab44c4a146100496497904,
title = "Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain",
abstract = "Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.",
author = "Burt, {David R.} and Creese, {I. A N} and Snyder, {Solomon H}",
year = "1977",
language = "English (US)",
volume = "196",
pages = "326--328",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4287",

}

TY - JOUR

T1 - Antischizophrenic drugs

T2 - Chronic treatment elevates dopamine receptor binding in brain

AU - Burt, David R.

AU - Creese, I. A N

AU - Snyder, Solomon H

PY - 1977

Y1 - 1977

N2 - Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

AB - Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

UR - http://www.scopus.com/inward/record.url?scp=0017599705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017599705&partnerID=8YFLogxK

M3 - Article

C2 - 847477

AN - SCOPUS:0017599705

VL - 196

SP - 326

EP - 328

JO - Science

JF - Science

SN - 0036-8075

IS - 4287

ER -

Access to Document