Abstract
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H)haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
Original language | English (US) |
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Pages (from-to) | 326-328 |
Number of pages | 3 |
Journal | Science |
Volume | 196 |
Issue number | 4287 |
DOIs | |
State | Published - 1977 |
ASJC Scopus subject areas
- General