Abstract
With only a few exceptions, the phenothiazines and butyrophenones used in the treatment of schizophrenia appear to exert antischizophrenic actions to the same or closely similar degrees. Both antischizophrenic and extrapyramidal effects apparently result from dopamine receptor blockade. Here, we report the influence of a variety of such antischizophrenic drugs on the brain's receptor for the muscarinic action of acetylcholine. Extrapyramidal effects are inversely proportional to affinity for the muscarinic receptor. Thus, drugs such as clozapine and thioridazine hydrochloride apparently owe their low incidence of extrapyramidal effects to anticholinergic properties that compensate for their intrinsic extrapyramidal effects. Our findings provide a means to predict extrapyramidal actions of new potential antischizophrenic drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-61 |
| Number of pages | 4 |
| Journal | Archives of General Psychiatry |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1974 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Psychiatry and Mental health
Cite this
Antischizophrenic Drugs and Brain Cholinergic Receptors : Affinity for Muscarinic Sites Predicts Extrapyramidal Effects. / Snyder, Solomon H; Greenberg, David; Yamamura, Henry I.
In: Archives of General Psychiatry, Vol. 31, No. 1, 1974, p. 58-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antischizophrenic Drugs and Brain Cholinergic Receptors
T2 - Affinity for Muscarinic Sites Predicts Extrapyramidal Effects
AU - Snyder, Solomon H
AU - Greenberg, David
AU - Yamamura, Henry I.
PY - 1974
Y1 - 1974
N2 - With only a few exceptions, the phenothiazines and butyrophenones used in the treatment of schizophrenia appear to exert antischizophrenic actions to the same or closely similar degrees. Both antischizophrenic and extrapyramidal effects apparently result from dopamine receptor blockade. Here, we report the influence of a variety of such antischizophrenic drugs on the brain's receptor for the muscarinic action of acetylcholine. Extrapyramidal effects are inversely proportional to affinity for the muscarinic receptor. Thus, drugs such as clozapine and thioridazine hydrochloride apparently owe their low incidence of extrapyramidal effects to anticholinergic properties that compensate for their intrinsic extrapyramidal effects. Our findings provide a means to predict extrapyramidal actions of new potential antischizophrenic drugs.
AB - With only a few exceptions, the phenothiazines and butyrophenones used in the treatment of schizophrenia appear to exert antischizophrenic actions to the same or closely similar degrees. Both antischizophrenic and extrapyramidal effects apparently result from dopamine receptor blockade. Here, we report the influence of a variety of such antischizophrenic drugs on the brain's receptor for the muscarinic action of acetylcholine. Extrapyramidal effects are inversely proportional to affinity for the muscarinic receptor. Thus, drugs such as clozapine and thioridazine hydrochloride apparently owe their low incidence of extrapyramidal effects to anticholinergic properties that compensate for their intrinsic extrapyramidal effects. Our findings provide a means to predict extrapyramidal actions of new potential antischizophrenic drugs.
UR - http://www.scopus.com/inward/record.url?scp=0016138354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016138354&partnerID=8YFLogxK
U2 - 10.1001/archpsyc.1974.01760130040006
DO - 10.1001/archpsyc.1974.01760130040006
M3 - Article
C2 - 4152054
AN - SCOPUS:0016138354
VL - 31
SP - 58
EP - 61
JO - JAMA Psychiatry
JF - JAMA Psychiatry
SN - 2168-622X
IS - 1
ER -